Three Novel Cases of Trilateral Retinoblastoma: An Approach towards Genetic Diagnosis


The heritable form of retinoblastoma associated with an intracranial tumour that mostly affects the pineal gland as well as the suprasellar or intrasellar region of the brain is known as trilateral retinoblastoma. Because of its rarity, only a few research on the molecular genetics of this tumour have been published, despite the importance of reporting these cases with molecular analyses. This study intends to raise awareness about retinoblastoma early detection and the use of intracranial magnetic resonance imaging to track subsequent cancers, such as trilateral retinoblastoma. More over half of the Because trilateral retinoblastoma is diagnosed by magnetic resonance imaging at the same time as retinoblastoma, baseline screening for trilateral retinoblastoma may be beneficial. In this work, we provide three examples with trilateral retinoblastoma, as well as the molecular data for each proband, as determined by magnetic resonance imaging.

Author (s) Details

Ms. Renata Mendes de Freitas
Department of Genetics and Molecular Biology, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil and The Federal University of Juiz de Fora, Brazil.

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