The Role of Melatonin in COVID-19 Treatment and in Neurocognitive Health – Commentary and Call to Action


The pineal hormone melatonin, which studies have shown to be a potent immunomodulator and whose primary function is the regulation of sleep-wake cycles, possesses an incredibly broad spectrum of anti-inflammatory, antioxidant, and antiapoptotic activity. It may also have potential cytoprotective, neuroprotective, nephroprotective, cardioprotective, anti-hypertensive, anti-nociceptive, and other protective effects. In this article and brief review, we examine the cutting-edge of the prospective use of the chronobiotic drug melatonin in the treatment of COVID-19 disease as well as its potential involvement in maintaining neurocognitive health and treating SARS-2-CoV infection. There is motivation for investigating the use of melatonin in the potential amelioration of some of the newly identified pathological neurocognitive sequelae, particularly the cognitive impairment that is increasingly manifest as part of the cluster known as post-acute sequelae of COVID-19 (PASC), aka “Long COVID,” given the recognized dysregulated neuro-inflammatory processes that underlie SARS-CoV-2 infection. In the process, we review clinical evidence of benefit in these areas, suggesting the strong promise that melatonin appears to offer, with excellent tolerability, minimal toxicity, affordability, self-administerability, and sufficiently strong evidence of efficacy to be actionable, in the here and now. We conclude with a call to action to promote and nurture additional study into the wide range of advantages of melatonin and to support its wise application within the current therapeutic environment.

Author(s) Details:

Constantine Kaniklidis,
No Surrender Breast Cancer Foundation (NSBCF), USA.

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Keywords: Melatonin, COVID-19 treatment, neurocognitive health, SARS-2-CoV

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