The Combination of L-lysine and Alloxan Induces Acute Necrotizing Pancreatitis in Rats: A Recent Study

The goal of this research was to see how L-lysine affected the pancreas of diabetic rats. Adult male Sprague-Dawley rats were split into four groups (each with six rats) and studied for 20 days. Control Group I (saline solution, i.p.). Group II: L-lysine (10 mM)-treated rats. Group III: Rats given 120 mg/kg of alloxan (diabetic control). Group IV: Alloxan plus L-lysine-treated rats. The glucose, triglyceride, and cholesterol levels were measured using blood taken from the aorta. As expected, glucose levels in Group III rats increased. Body weight decrease was also found (p 0.001). On the tenth day of the trial, diabetic control rats had greater glucose concentrations than rats in Group IV. L-lysine given to intact animals had an effect on the pancreas, according to the findings. Animals who have previously received alloxan injections exhibited more pancreatic damage. Hyperglycemia was clearly caused by a single dose of L-lysine. This impact is increased when L-lysine is coupled with alloxan. We can now offer a new rat model of acute pancreatitis based on these findings.

Author (S) Details

José D. Méndez
Medical Research Unit in Metabolic Diseases, Cardiology Hospital, National Medical Center, Mexican Institute of Social Security, México

Jianling Xie
Nutrition and Metabolism South Australia Health & Medical Research Institute, Adelaide, Australia.

Verna Méndez-Valenzuela
General Hospital 49, Mexican Institute of Social Security, Los Mochis, Sinaloa, México.

José L. Martínez
Department of General and Gastrointestinal Surgery, Specialities Hospital, National Medical Center, Mexican Institute of Social Security, México.

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