Tag: proteinuric disease

Cyclosporine A Nephrotoxicity: Downregulation of Multiple Drug Resistance-Associated Protein 2 (MRP2) by Upregulated miRNA133a: Its Importance in Renal Transplantation and Treatment of Proteinuric Disease Such as FSGS

Background: MRP2 (multiple drug resistance-associated protein 2) is a xenobiotic transport protein that includes cyclosporine A. (CyA). MRP2 is downregulated in minimal change nephrosis (MCN) and membranous nephropathy by miRNA133a binding to its 3UTR region, which is triggered by endothelin-1 (ET-1) via the ETB-receptor (MN). The status of CyA as a therapy option for focal-segmental […]

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