Tag: myocardial ischemia/ reperfusion

Apocynin Exerts Dose-Dependent Cardioprotective Effects by Attenuating Reactive Oxygen Species in Ischemia/Reperfusion: A Recent Study

Because of increased reactive oxygen species and decreased endothelial-derived nitric oxide bioavailability, ischemia/reperfusion causes cardiac contractile failure and cell death. Endothelial dysfunction, which develops within 5 minutes of reperfusion, contributes to ischemia/reperfusion injury. Normally, NADPH oxidase creates reactive oxygen species to aid cell signalling and differentiation; however, excessive release of these species after ischemia exacerbates […]

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