Study on the Role of Cell Signaling Molecules in the Pathogenesis of Glomerulonephritis in Children

Background: Cytokines are a functional group of small proteins and glycoproteins that serve as soluble mediators in an autocrine or paracrine way. Cytokines are produced by a range of cell types, the majority of which are leukocytes, and they have immune and non-immune cells as their targets.

The goal of the study was to determine the concentration of cellular signalling molecules in the urine of children with glomerulonephritis at various clinical-evolutionary stages.

Materials and Procedures: 75 children with glomerulonephritis (GN) ranging in age from 2 to 17 were included in this study. Steroid-sensitive nephrotic syndrome (SSNS), steroid-resistant nephrotic syndrome (SRNS), chronic glomerulonephritis (GN) nephrotic form, and chronic GN mixed type were found in 20 children. This study looked at patients who had relapsed from disease or were in clinical remission. The control group consisted of 20 healthy children.

Increased levels of cell signalling molecules (IL-8, TNF-, MCP-1, MIP-1) in the urine during clinical symptoms were discovered in this study, which is a notable result considering their role in the immunopathogenic mechanism of proteinuria in nephrotic syndrome (NS).

Conclusions: Using urinary concentrations of cellular signalling molecules as a non-invasive predictive method for estimating disease activity, monitoring disease progression, distinguishing steroid-sensitive nephrotic syndrome from steroid-resistant nephrotic syndrome, and assessing treatment effectiveness in children with glomerulonephritis could be beneficial.

Author(S) Details

Angela Ciuntu
Department of Pediatrics, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova. and Institute of Mother and Child, Chisinau, the Republic of Moldova.

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