The sensitivity of Mycobacterium tuberculosis isolates from suspected tuberculosis patients to snail seromucous and chitosan as an alternative to anti-tuberculosis medications is highlighted in this study.
The findings of this study are based on laboratory tests.
Management specimen, freeze-drying of snail seromucous, formulation of dosage preparation, identification of MTB isolates, and drug susceptibility testing (DST) of MTB isolates to snail seromucous, chitosan, and ATD are all aspects of the research (streptomycin, isoniazid, rifampicin, and ethambutol). The M. tuberculosis isolates utilised in the study were obtained from the findings of microscopic smear inspection and molecular rapid test (MRT) utilising Genexpert tools on sputum samples from suspect tuberculosis patients. When compared to SIRE, M. tuberculosis isolates from patients with tuberculosis are resistant to snail seromucous and chitosan. Snail seromucous is 8,000 mg per litre, chitosan 2% is 800 mg per litre, streptomycin is 800 mg per litre, isoniazid is 20 mg per litre, rifampicin is 8000 mg per litre, and ethambutol is 200 mg per litre (SIRE). The percentage of resistance of M. tuberculosis isolates to snail seromucous, chitosan, and ATD was calculated.
When compared to SIRE, the results demonstrated that M. tuberculosis isolates from patients with tuberculosis are resistant to seromucous of the snails and chitosan. The efficiency of a bactericidal or bacteriostatic treatment against M. tuberculosis isolates can be influenced by physiological bacterial cells as genetic variables related to resistance or cell pathogenicity, as well as mutation caused by mutagenic agents in physical chemistry from environmental factors. As a result, more research into the larger number of samples and the creation of test preparations in conjunction with ATD is required.
Author (s) Details
Dr. Yusup Subagio Sutanto
Department of Pulmonology and Respiartory Medicine, Faculty of Medicine, Sebelas Maret University of Surakarta, Indonesia.
Dr. Magdalena Sutanto
Surakarta City Regional General Hospital and Dr. Oen Solo Baru Hospital, Surakarta, Indonesia.
Dr. Agnes Sri Harti
Department of Nursing Study Program, Faculty of Health Sciences, Kusuma Husada University, Surakarta, Indonesia.
Dr. Nony Puspawati
Health Analyst Study Program, Faculty of Health Sciences, Setia Budi University, Surakarta, Indonesia.
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