Study on Silica Catalyst Promoted One-Pot Synthesis of 4-[(Dialkylamino)methyl]-1,7- diphenylhepta-1,6-diene-3,5-dione

Silica (SiO2) catalyses 4-[(dialkylamino)methyl]-1,7-diphenylhepta-1,6-diene-3,5-dione single-pot synthesis. The expeditious synthesis of Mannich base derivatives under the microwave irradiation process for curcumin is known for its biological activity. Curcumin is naturally occurring, isolated from Curcuma longa, yellow pigments, structurally polyphenolic compounds consisting of spectacular biological activity. Curcumin, which is grown in most parts of India, is also called ‘Indian Saffron.’ In many Asian countries, such as ‘India’ and ‘China’, curcumin has historically been recognised for its medicinal property. However, due to its poor bioavailability, the therapeutic usefulness of curcumin is limited. Present technique provides one pot catalysed silica, a productive approach for obtaining Mannich base curcumin. Conventional and microwave irradiation techniques have also been shown to be productive. A non-toxic, non-hazardous, readily accessible eco-friendly catalyst used for the synthesis of curcumin analogue under traditional and microwave irradiation methods. An expeditious response with good to better performance performed under the microwave process. 1H NMR was used to classify the final items.

Author(s) Details

Dr. Mahesh G. Shioorkar
Department of Chemistry, Vivekanand Arts, S.D. Commerce and Science College, Aurangabad-431 001, India.

Professor Milind B. Ubale
Department of Chemistry, Vasantrao Naik College, Aurangabad-431 001, India.

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