Study on a Rare Case of a Solitary Laryngeal Xanthoma and Its Clinical Implications


Xanthomas are lipid-containing histiocytic foam cells that infiltrate the dermis or tendons in a limited infiltration. The current study focuses on a rare case of a solitary laryngeal xanthoma in a 42-year-old man who had been complaining of hoarseness and voice fatigue for a year. During a flexible laryngoscopic examination, a smooth surfaced polypoidal mass with a yellowish tinge emerging from the membranous left vocal cord was detected. There were no other lesions on his body that were identical. Histopathological investigation revealed remnants of stratified squamous epithelium with sub-epithelium revealing sheets of foamy cells after a transoral-endoscopic mass excision. After CD68 immunohistochemistry revealed a single laryngeal xanthoma, a diagnosis of single laryngeal xanthoma was obtained. Despite the fact that the patient’s follow-up revealed no recurrence, investigations revealed newly developed dyslipidemia. As a result, even in individuals who are not known cases of dyslipidemia, a diagnosis of a solitary laryngeal xanthoma, even if there are no additional lesions, demands a full investigation, including a lipid profile. This is especially important in a nation like India, where a large number of cases of dyslipidemia go undiagnosed, leading to atherosclerosis and possibly future cardiac problems.

Author (s) Details

Bharathi Murundi Basavarajaiah
Department of ENT,JSS Medical College, JSS Academy of Higher Education and Research (JSSAHER), Mysuru, Karnataka, India.

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