Study of Synthesis, Spectroscopic Characterization and Their Antidiabetic Activity of Some Water Soluble Zn(II) Complexes with N,S-donor Ligands Derived from (E)-N-(Thiophen-2-ylmethylene)anilines

Five new [ZnX2L1-3] composition zinc (II) nitrate complexes (where X = Cl-, NO3-; Ln = (E)-N-(thiophen-2-ylmethylene) anilines (1-5)) were synthesised. Elemental analysis, UV-visible, fluorescence, IR and 1H NMR spectroscopy characterised the complexes. Efforts to produce a single crystal suitable for the structure of the X-ray crystal could not be accomplished. However, it was proposed that the complexes follow four coordinated tetrahedral and six coordinated octahedral geometry from spectroscopic data. All complexes were obtained at moderate to good yields and in acetonitrile solution, these compounds act as non-electrolytes. UV-Visible and fluorescence spectral analysis of ligand to ligand charge transfer transition suggested (intra-ligand) ligand complexes 1-5. The complexes were screened against the alpha-glucosidase enzyme for their anti-diabetic activity and contrasted with the regular drug acarbose. The enzyme activity inhibition concentration (IC50) was determined by a systematic enzyme assay. Appropriate controls were used for samples and triplicate analysis was done. The analysis of the complexes suggested a geometry of four and six coordinates around the atom of zinc. Complexes 1-3 were four coordinated tetrahedral structures, while 6 coordinated octahedral structures were complexes 4 and 5. Among the studied compounds, compound 1 was found to exhibit effective anti-diabetic activity.

Author(s) Details

Dr. Sajal Kundu
Department of Chemistry, National Institute of Technology Agartala, Jirania-799 046, Tripura, India.

Dr. Keisham Surjit Singh
Department of Chemistry, Manipur University, Canchipur-795003, India.

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