‘Silver’ is a magical metal that has been a part of human history since the dawn of humanity. Silver nanoparticles (AgNPs) have become more popular in pharmaceutical and consumer applications due to their potent antimicrobial properties. AgNPs’ organismal toxicity is well documented, despite their widespread use in consumer items. As a result, the current work used Drosophila melanogaster as a model system to investigate the developmental and immunogenic responses of laboratory produced AgNPs. The current study used Drosophila as a model system to investigate the complete characterisation of AgNPs in order to better understand their biological repercussions, including genetic, chromosomal, and developmental biological endpoints. PVP-coated AgNPs were produced in the lab and characterised for size, shape, and surface morphology. AgNPs had dose-dependent impacts on numerous biological processes due to their direct interaction with amines. Male mate preference was found to be negatively affected by doses greater than 0.1 mM in terms of life cycle, fecundity, longevity, and courting behaviour. AgNPs were also observed to influence injury-induced melanogenesis in larvae, implying a damaged innate immune system as well as the melanin synthesising pathway. The absence of melanization was observed in adults as well. These findings show that AgNP has developmental and immunogenic effects in Drosophila, one of the most well-studied animal models.
Kanchan A. Phatak
Department of Zoology, Nowrosjee Wadia College, Pune-411001, India..
Pawan Kumar Khanna
Department of Applied Chemistry, Defence Institute of Advanced Technology (DIAT), Girinagar, Pune-411025, India
Bimalendu B. Nath
Stress Biology Research Laboratory, Department of Zoology, Savitribai Phule Pune University, Pune-411007, India.
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