Rosai-Dorfman disease (SHML) is characterised by a distorted lymph node architecture with marked dilation of lymphatic sinuses occupied by numerous lymphocytes, as well as histiocytes with vesicular nuclei and abundant clear cytoplasm with phagocytized lymphocytes or plasma cells, also known as ’emperipolesis.’ Early treatment is essential. A poor prognosis is even worse by a late diagnosis and extensive lymph node involvement. Rosai-Dorfman illness was identified in a 29-year-old Indian lady with a 4-month history of a painful unilateral cervical tumour and low-grade fever. The definitive diagnosis was made via a fine needle aspiration (FNA) biopsy of the cervical lymph node. Finally, because of the unique cytological features of SHML, FNA biopsy may be sufficient to diagnose the majority of patients, avoiding potentially unneeded invasive treatments. Histopathological and immunohistochemical tests can be used to diagnose the condition.


Author (s) Details

Dr. Jyotika Waghray
Kunal Institute of Medical Specialities, Hyderabad, Telangana, India.

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