Overview on the Role of Proteins as the Molecular Markers of Male Fertility

Proteins play a key role in many functions such as metabolic activity, differentiation, as cargos and
cell fate regulators. It is necessary to know about the markers involved in male fertility in order to
develop remedies for the treatment of male infertility. But, the role of the proteins is not limited to
particular function in the biological systems. Some of the proteins act as ion channels such as catsper
and proteins like Nanos acts as a translational repressor in germ cells and expressed in prenatal
period whose role in male fertility is uncertain. Rbm5 is a pre mRNA splicing factor necessary for
sperm differentiation whose loss of function results deficit in sperm production. DEFB114 is a beta
defensin family protein necessary for sperm motility in LPS challenged mice where as TEX 101 is a
plasma membrane specific germ cell protein whose function is not clearly known u to now. Gpr56 is
another adhesion protein whose null mutation leads to arrest of production of pups in rats. Amyloid
precursor protein role in Alzheimer’s disease is already known but it plays an important role in male
fertility also but its function is uncertain and has to be considered while targeting APP during the
treatment of Alzheimer’s disease. The study on amyloid precursor protein in male fertility is a novel
thing but requires further study in correlation to alzheimer’s disease.

Author(s) Details

Dr. Eswari Beeram
Department of Biochemistry, Sri Venkateswara University, Tirupati, A.P., India.

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