Due to inadequate and delayed treatment, cholangiocarcinoma (CCA), an aggressive bile duct cancer, has a significant fatality rate. In order to understand the relationship between Notch signalling and CCA in aetiology, progression, and prospective molecular targets for CCA regulation, a comprehensive review of the literature was conducted. Using the search phrases “cholangiocarcinoma” AND “Notch signalling,” the data from the three databases (PubMed, ScienceDirect, and Scopus). Out of 90 papers that met the qualifying requirements, 28 were included in the analysis. CCA formation and progression are activated by the overexpression/increase of Notch ligands, such as Jagged1 and Notch receptor (Notch1, Notch2, and Notch3), as well as by the upregulation of the downstream Notch signalling. A potential strategy for halting CCA development and progression appears to be the downregulation of Notch1 signalling by a number of treatments. The Notch signalling pathway should be investigated through CCA control as a potential target.

Author(s) Details:

Peeranate Vanaroj,
Chulabhorn International College of Medicine, Thammasat University, Paholyothin Road, Klonglung, Pathumthani, Thailand.

Wanna Chaijaroenkul,
Chulabhorn International College of Medicine and Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Thammasat University, Paholyothin Road, Klonglung, Pathumthani Thailand.

Kesara Na-Bangchang,
Chulabhorn International College of Medicine and Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Thammasat University, Paholyothin Road, Klonglung, Pathumthani Thailand.

Please see the link here: https://stm.bookpi.org/CPMS-V2/article/view/7348

Keywords: Cholangiocarcinoma, notch signaling, notch 1, notch 2, notch 3.