News Update on Glucan Research: Aug – 2019

Dectin-1 Is A Major β-Glucan Receptor On Macrophages

Zymosan could be a β-glucan– and mannan-rich particle that’s wide used as a cellular substance for examining the many responses accomplished by phagocytes. The phagocyte mannose receptor (MR) and complement receptor three (CR3) have traditionally been thought-about the most important phagocyte lectins concerned within the nonopsonic recognition of those yeast-derived particles. victimization specific sugar inhibitors, we have a tendency to show that a β-glucan receptor, however not the adult male, could be a predominant receptor concerned during this method. what is more, nonopsonic zymosan binding was unaffected by genetic CD11b deficiency or a block antibody (mAb) against CR3, demonstrating that CR3 wasn’t the β-glucan receptor mediating this activity. [1]

Oat beta-glucan reduces blood cholesterol concentration in hypercholesterolemic subjects

OBJECTIVE: many studies have indicated that consumption of oat bran lowers blood sterol and this result has been attributed specifically to oat bran’s soluble fiber (beta-glucan). This study was designed to check this hypothesis. DESIGN: The refined fibre (oat gum, eightieth beta-glucan) was isolated, and agglomerative within the presence of maltodextrin to facilitate dispersion during a drink. Subjects consumed the oat gum (2.9 g beta-glucan), or maltodextrin placebo, double daily for four weeks, during a irregular, cross-over style with a three week wash-out between phases. Consumption was love a daily dose of concerning seventy g of oat bran. SETTING: The study was with nonparasitic people. SUBJECTS: Twenty hypercholesterolemic male and feminine adults entered, and nineteen completed, the study. [2]

The effects of β-glucan on human immune and cancer cells

Non-prescriptional use of healthful herbs among cancer patients is common round the world. The alleged anti-cancer effects of most flavoring extracts area unit primarily supported studies derived from in vitro or in vivo animal experiments. the present data suggests that these flavoring extracts exert their biological impact either through cytotoxic or immunomodulatory mechanisms. one among the active compounds liable for the immune effects of flavoring merchandise is within the sort of advanced polysaccharides referred to as β-glucans. β-glucans area unit ubiquitously found in each microorganism or flora cell walls and are concerned within the initiation of anti-microbial response. [3]

A combination of yeast beta-glucan and milk hydrolysate is a suitable alternative to zinc oxide in the race to alleviate post-weaning diarrhoea in piglets

Zinc oxide (ZnO) is presently used as a dietary supplement to support gut equilibrium throughout the quality ‘abrupt’ substitution practices in business pig production. However, a replacement is desperately needed as a ban on ZnO usage is at hand. the target of this study was to explore the potential of a bovine casein product (5kDaR) and yeast β-glucan, and their combination, as another to ZnO. Eighty 21d previous male piglets received a basal diet or supplemented with 5kDaR and yeast β-glucan alone or together, or ZnO from the day of substitution and were monitored for ten days (n = 8/group; dietary groups: management diet; control diet + 5kDaR; control diet + yeast β-glucan; control diet + 5kDaR + yeast β-glucan; control diet + ZnO). [4]

Molecular Characterization Using gtf Gene Detection and Medium Optimization of Beta-D-Glucan Production from Pediococcus parvulus F1030 Isolated from Local Egyptian Boza

Background: carboxylic acid microorganism (LAB) have nice advantages which may improve the nutritionary worth of food, reduces some infections, immune modulator result, curbs some varieties of cancer and restricts aldohexose level of bodily fluid.

Aims: This study was meted out to notice glycosyltransferase sequence (gtf) encryption glucosyltransferase protein chargeable for beta-D-glucan production in  Pediococcus parvulus F1030 that is isolated by authors from native Egyptian Boza (local alcoholic beverage), and enhancing its production by medium optimisation. [5]

Reference

[1] Brown, G.D., Taylor, P.R., Reid, D.M., Willment, J.A., Williams, D.L., Martinez-Pomares, L., Wong, S.Y. and Gordon, S., 2002. Dectin-1 is a major β-glucan receptor on macrophages. Journal of Experimental medicine, 196(3), pp.407-412. (Web Link)

[2] Braaten, J.T., Wood, P.J., Scott, F.W., Wolynetz, M.S., Lowe, M.K., Bradley-White, P. and Collins, M.W., 1994. Oat beta-glucan reduces blood cholesterol concentration in hypercholesterolemic subjects. European journal of clinical nutrition, 48(7), pp.465-474. (Web Link)

[3] Chan, G.C.F., Chan, W.K. and Sze, D.M.Y., 2009. The effects of β-glucan on human immune and cancer cells. Journal of hematology & oncology, 2(1), p.25. (Web Link)

[4] A combination of yeast beta-glucan and milk hydrolysate is a suitable alternative to zinc oxide in the race to alleviate post-weaning diarrhoea in piglets
Anindya Mukhopadhya, John V. O’Doherty & Torres Sweeney
Scientific Reportsvolume 9, Article number: 616 (2019) (Web Link)

[5] Ghany, K., Hamouda, R. A., Mahrous, H. A., Sharaf, S. and Hamza, H. A. (2018) “Molecular Characterization Using gtf Gene Detection and Medium Optimization of Beta-D-Glucan Production from Pediococcus parvulus F1030 Isolated from Local Egyptian Boza”, Journal of Pharmaceutical Research International, 20(5), pp. 1-8. doi: 10.9734/JPRI/2017/39079. (Web Link)

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