News Update on Enzymes Research: Aug – 2019

Biomass Recalcitrance: Engineering Plants and Enzymes for Biofuels Production

Lignocellulosic biomass has long been recognized as a possible property supply of mixed sugars for fermentation to biofuels and alternative biomaterials. many technologies are developed throughout the past eighty years that enable this conversion method to occur, and also the clear objective now could be to create this method cost-competitive in today’s markets. Here, we tend to think about the natural resistance of plant cell walls to microorganism and accelerator deconstructionism, conjointly referred to as “biomass unmanageableness.” it’s this property of plants that’s for the most part chargeable for the high price of lignocellulose conversion. [1]

Antioxidant enzymes and human diseases

Objectives: to explain the importance of the inhibitor enzymes SOD, antioxidant, and enzyme operating along in human cells against poisonous reactive atomic number 8 species, their relationship with many pathophysiologic processes and their potential therapeutic implications. [2]

Soil Enzymes

Soil could also be looked upon as a biological entity. Soils contain free catalysts; immobilized living thing enzymes stabilised by a three‐dimensional network of macromolecules and enzyme proteins at intervals microbic cells. every of the organic and mineral fractions in each bulk soil and rhizosphere includes a special influence on the overall protein activity of that soil. The study of enzymes, in general, may be a subject of interest to several disciplines in science starting from biology to physical sciences. [3]

Human metallo-β-lactamase enzymes degrade penicillin

Nonribosomal peptides are assemblages, together with antibiotics, of canonical amino acids and different molecules. β-lactam antibiotics act on microorganism cell walls and may be cleaved by β-lactamases. β-lactamase activity in humans has been neglected, even supposing eighteen enzymes have already been annotated such in human order. Their chemical reaction activities on antibiotics haven’t been antecedently investigated. Here, we tend to report that human cells were able to digest antibiotic drug and this activity was inhibited  by β-lactamase substance, i.e. sulbactam. antibiotic drug degradation in human cells was microbiologically incontestible on diplococcus. [4]

Hepatic Involvement with Elevated Liver Enzymes in Nepalese Subjects with Type 2 Diabetes Mellitus

Background: DM (DM) is characterised by a broad disturbance in metabolism. Since the liver plays a significant role within the regulation of metabolism, there’s proof of liver disfunction in DM. there’s a high prevalence of non-alcoholic malady} disease among diabetic patients in western countries. However, there’s a scarceness of knowledge showing of such association in Nepalese patients with DM. Therefore, this study was dole out for a far better understanding of alteration of liver operate in patients with kind two DM (T2DM). [5]

Reference

[1] Himmel, M.E., Ding, S.Y., Johnson, D.K., Adney, W.S., Nimlos, M.R., Brady, J.W. and Foust, T.D., 2007. Biomass recalcitrance: engineering plants and enzymes for biofuels production. science, 315(5813), pp.804-807. (Web Link)

[2] Matés, J.M., Pérez-Gómez, C. and De Castro, I.N., 1999. Antioxidant enzymes and human diseases. Clinical biochemistry, 32(8), pp.595-603. (Web Link)

[3] Tabatabai, M.A., 2003. Soil enzymes. Encyclopedia of Agrochemicals. (Web Link)

[4] Human metallo-β-lactamase enzymes degrade penicillin
Seydina M. Diene, Lucile Pinault, Vivek Keshri, Nicholas Armstrong, Saber Khelaifia, Eric Chabrière, Gustavo Caetano-Anolles, Philippe Colson, Bernard La Scola, Jean-Marc Rolain, Pierre Pontarotti & Didier Raoult
Scientific Reportsvolume 9, Article number: 12173 (2019) (Web Link)

[5] Shrestha, N., Prasad Bhatt, N., Neopane, P., Dahal, S., Regmi, P., Khanal, M. and Shrestha, R. (2017) “Hepatic Involvement with Elevated Liver Enzymes in Nepalese Subjects with Type 2 Diabetes Mellitus”, International Journal of Biochemistry Research & Review, 16(1), pp. 1-8. doi: 10.9734/IJBCRR/2017/31935. (Web Link)

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