News Update on Corneal Research: Dec – 2019

Corneal Graft Survival and Visual Outcome: A Multicenter Study

Purpose: The reconstructive surgery Follow-up Study has followed 2385 membrane transplants performed inside the united kingdom and conjointly the Republic of ireland for up to 450 days to quantify factors influencing surgical procedure survival and visual outcome 3 and twelve months postoperatively.

Methods: advanced analyses of grafts registered by kingdom Transplant Support Service from July 1987 to Gregorian calendar month 1990 were used. Corrected modality of functioning grafts was assessed at 3 and twelve months. [1]

Corneal neovascularization

Corneal neovascularization (NV) may be a sight-threatening condition typically related to inflammatory or infectious disorders of the ocular surface. it’s been shown within the field of cancer growing analysis that a balance exists between angiogenic factors (such as embryonic cell protein and tube-shaped structure epithelial tissue growth factor) and anti-angiogenic molecules (such as angiostatin, endostatin, or pigment epithelial tissue derived factor) within the tissue layer. many inflammatory, infectious, chronic, and traumatic disorders area unit related to tissue layer Silver State, within which the balance is canted towards growing. [2]

Corneal response to orthokeratology.

PURPOSE:The technique of orthokeratology produces a tissue layer response to the mechanical pressures exerted by rigid contact lenses. This paper reports a study that investigated the geographics and pachometric tissue layer changes induced  by orthokeratology. METHODS:Six young myopic subjects (11 eyes) wore “accelerated orthokeratology” lenses (OK-74; Contex INC., Sherman Oaks, CA) in a very high Dk material (AirPerm; Dk = 88) for twenty eight days. tissue layer and animal tissue thickness were measured topographically victimisation the Holden-Payor optical micropachometer, and tissue layer topography was monitored victimisation the EyeSys system. RESULTS:Refractive error amendment reached one.71  0.59 D reduction in shortsightedness once twenty eight days. once one day of lens wear, statistically important central tissue layer flattening was noted, that progressed to achieve zero.22  0.07 mm (1.19  0.38 D) at twenty eight days. [3]

Changes in the corneal thickness and limbus after 1 year of scleral contact lens use

Purpose: To assess the physiological changes within the membrane over time in patients with irregular membrane fitted with Rose Dapsang XL gas-permeable scleral contact lenses.

Methods: Prospective study of sixteen eyes of patients WHO failed to tolerate gas-permeable tissue layer contact lenses and were fitted with Rose Dapsang XL scleral lenses. we tend to assessed the central vault and therefore the tissue layer thickness centrally and at peripheral regions (2 to 5 mm annulus). of these measures were obtained by anterior phase optical coherence picturing. The measurements were taken at once when fitting the lenses and one, half dozen and twelve months later. before the study and at one year, we tend to performed AN objective take a look at for diagnosis limbal vegetative cell deficiency (Limbokit). [4]

Photochemical Kinetic Modeling for Oxygen-enhanced UV-light-activated Corneal Collagen Crosslinking

Aims: To derive analytic formulas for the effectivity of type-II tissue layer albuminoid crosslinking (CXL) supported coupled macroscopical kinetic equations with a stress on the role of chemical element.

Study Design: modeling and analysis of type-II cardinal

Place and period of Study: Taipeh, Taiwan, between February. and Gregorian calendar month 2017.

Methodology: Coupled macroscopical kinetic equations ar derived below the quasi-steady state condition. For type-I cardinal, the ovoflavin triplet state [RF3] interacts directly with the stroma albuminoid substrate for crosslinking. For type-II method, [RF3] interacts with the ground-state chemical element [O2] to create a reactive chemical element undershirt (ROS) which might relax to [O2], or move with the animate thing matrix for crosslinking. [5]


[1] Vail, A., Gore, S.M., Bradley, B.A., Easty, D.L., Rogers, C.A. and Collaborators, C.T.F.U.S., 1994. Corneal graft survival and visual outcome: a multicenter study. Ophthalmology, 101(1), (Web Link)

[2] Chang, J.H., Gabison, E.E., Kato, T. and Azar, D.T., 2001. Corneal neovascularization. Current opinion in ophthalmology, 12(4), (Web Link)

[3] Swarbrick, H.A., Wong, G. and O’Leary, D.J., 1998. Corneal response to orthokeratology. Optometry and vision science: official publication of the American Academy of Optometry, 75(11), (Web Link)

[4] Changes in the corneal thickness and limbus after 1 year of scleral contact lens use
Beatriz de Luis Eguileor, Arantxa Acera, Alaitz Santamaría Carro, Raquel Feijoo Lera, Julene Escudero Argaluza & Jaime Etxebarria Ecenarro
Eye (2019) (Web Link)

[5] Lin, J.-T. (2017) “Photochemical Kinetic Modeling for Oxygen-enhanced UV-light-activated Corneal Collagen Crosslinking”, Ophthalmology Research: An International Journal, 7(1), (Web Link)

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