News Update on Chlorpyrifos Research: June – 2019

Environmental Fate of Chlorpyrifos

Chlorpyrifos may be a member of the organophosphorus or insect powder category of pesticides. This category has become one in all the foremost wide used teams of gadfly management chemicals. In 1989 nearly four-hundredth of the $6.2 billion international insect powder market was comprised of organophosphates (OPs) (Phillips and McDougall 1990). though Clermont (1854) had initial synthesized tetraethylpyrophosphate (TEPP), it absolutely was not till abundant later that the insecticidal properties of this OP were delineate (Schrader 1942). This milestone semiconductor diode to more artificial work with insecticidal Roman deity and therefore provided the impetus that will result in the launch of a completely new category of pesticides. Early Roman deity found to be efficacious for insect management and therefore brought into widespread use enclosed insect powder (1944) and insecticide (1952) (Matsumura 1985). These successes aroused more discovery work on the a part of artificial chemists and entomologists inside variety of analysis organizations. [1]

Chlorpyrifos: Pharmacokinetics in human volunteers

The dynamics of organophosphate, associate organophosphorothioate pesticide, and its principal matter, 3,5,6-trichloro-2-pyridinol (3,5,6-TCP), were investigated in six healthy male volunteers given one zero.5 mg/kg po and, a pair of or a lot of weeks later, a 0.5 or 5.0 mg/kg dermal dose of organophosphate. No signs or symptoms of toxicity or changes in blood cell enzyme were ascertained. Plasma enzyme was depressed to fifteen of predose levels by the zero.5 mg/kg po dose however was basically unchanged following the five.0 mg/kg dermal dose. Blood organophosphate concentrations were extraordinarily low… [2]

Developmental cholinotoxicants: nicotine and chlorpyrifos.

The stimulation of cholinergic receptors in target cells throughout a essential organic process amount provides signals that influence cell replication and differentiation. consequently, environmental agents that promote cholinergic activity evoke neurodevelopmental harm thanks to the inappropriate temporal order or intensity of stimulation. vasoconstrictor evokes mitotic arrest in brain cells possessing high concentrations of nicotinic cholinergic receptors. additionally, the cholinergic overstimulation programs the expression of genes that evoke programmed cell death and delayed cell loss. Effects of enzyme inhibitors exhibit several similarities to those of vasoconstrictor. organophosphate administered to developing rats in doses that don’t evoke signs of overt  toxicity decreased  polymer synthesis and caused shortfalls in cell numbers in brain regions enriched in cholinergic innervation. In embryo cultures, organophosphate conjointly elicited programmed cell death throughout neurulation. However, organophosphate conjointly evokes noncholinergic disruption of cell development by meddling with cell sign via adenylyl cyclase, resulting in widespread disruption that’s not restricted to cholinergic systems. we’ve got tested this hypothesis in vitro with PC12 cells, that lack the enzymes necessary to supply organophosphate oxon, the matter that inhibits enzyme. organophosphate strangled polymer synthesis in dedifferentiated PC12 cells, that have comparatively few cholinergic receptors. what is more, organophosphate was more practical than vasoconstrictor and its effects weren’t blocked by cholinergic antagonists. once cells were allowed to differentiate within the presence of organophosphate, cell replication was strangled even a lot of deeply and cell acquisition was inactive. At higher concentrations, organophosphate conjointly strangled neuritic outgrowth. Thus, organophosphate elicits harm by each noncholinergic and cholinergic mechanisms extending from early stages of neural cell replication through late stages of axonogenesis and terminal differentiation. consequently, the window of organic process vulnerability to organophosphate is probably going to increase from the embryonic amount into postpartum life. [3]

Paraoxonase status and plasma butyrylcholinesterase activity in chlorpyrifos manufacturing workers

Chlorpyrifos is associate degree organophosphorus (OP) medicine insect powder. Paraoxonase (PON1) is associate degree accelerator found in liver and plasma that hydrolyzes variety of OP compounds. PON1 polymorphisms embody a amino acid (Q)/arginine (R) substitution at position 192 (PON1Q192R) that affects reaction of OP substrates, with the PON1192Q allotype hydrolyzing organophosphate oxon less with efficiency than the PON1192R allotype, a variation probably vital in crucial status to organophosphate. we tend to studied fifty three organophosphate employees and sixty referents throughout one year and calculable chlorpyrifos exposure mistreatment industrial hygiene and employment records and excretion of the chlorpyrifos matter 3,5,6-trichloro-2-pyridinol (TCP). Plasma butyrylcholinesterase (BuChE) activity, which can by restrained by organophosphate exposure, was measured monthly. additionally, plasma samples were assayed for paraoxonase (PONase), diazoxonase (DZOase), and chlorpyrifosoxonase (CPOase) activity to see PON1 standing (inferred genotypes and their useful activity). simple regression analyses sculpturesque BuChE activity as a operate of organophosphate exposure and covariates. we tend to postulated that the amount of CPOase activity and therefore the inferred PON1192 genotype (together reflective PON1 standing) would disagree between teams which PON1 status would modify the models of organophosphate exposure on BuChE activity. organophosphate employees and referents had a 100-fold distinction in accumulative chlorpyrifos exposure. Contrary to our hypotheses, mean CPOase activity was similar in each teams (P=0.58) and PON1192Q showed a small overrepresentation, not associate degree underrepresentation, within the organophosphate cluster compared with referents (PON1192QQ, fifty one organophosphate, four-hundredth referent; PON192QR, forty third organophosphate, four-hundredth referent; PON192RR, 6 June 1944 organophosphate, 2 hundredth referent, P=0.08). In our models, BuChE activity was considerably reciprocally related to measures of interim organophosphate exposure, however the biological effects of organophosphate exposure on BuChE activity weren’t changed by PON1 inferred genotype or CPOase activity. [4]

Contamination Levels of Organochlorine and Organophosphorous Pesticide Residues in Water and Sediment from River Owena, Nigeria

River Owena functions because the supply of water for the Owena dam that provides beverage to the communities within the region, the watercourse additionally plays a crucial economic role in irrigation and fish farming within the region. however there has been AN indiscriminate used of chemical as a result of residents of the study space aren’t well oriented regarding the negative impact of chemical within the atmosphere. Analysis of organochlorine and organophosphorous chemical residues was administrated in water and sediment from watercourse Owena, the target of the analysis is to see the contamination levels of organochlorine and organophosphorous chemical within the water and sediment of watercourse Owena. Analysis was administrated victimisation gas activity including negatron capture detector so as to spot and quantify the concentration of organochlorine and organophosphorous chemical within the water and sediment samples from watercourse Owena. Analysis disclosed the contamination of water and sediment with organophosphorous chemical residues at totally different contamination levels in each dry and season, whereas an occasional levels of organochlorine chemical residues solely throughout the time of year. The TOPP for sediment samples ranges from one.045mg/L throughout the time of year and a couple of.279mg/L throughout the season, whereas the TOPP for water samples ranges from seven.163mg/L throughout the time of year to seven.83mg/L throughout the season. The TOCP values ranges from one.288mg/L to zero.015mg/L for sediment and water samples severally throughout the time of year, whereas organochlorine pesticides weren’t detected throughout the season. The incidence and seasonal variation of organophosphorous chemical residues in watercourse Owena will be attributed to the extreme agricultural and concrete activities within the neighborhood of watercourse Owena. [5]


[1] Racke, K.D., 1993. Environmental fate of chlorpyrifos. In Reviews of environmental contamination and toxicology (pp. 1-150). Springer, New York, NY. (Web Link)

[2] Nolan, R.J., Rick, D.L., Freshour, N.L. and Saunders, J.H., 1984. Chlorpyrifos: pharmacokinetics in human volunteers. Toxicology and applied pharmacology, 73(1), pp.8-15. (Web Link)

[3] Slotkin, T.A., 1999. Developmental cholinotoxicants: nicotine and chlorpyrifos. Environmental Health Perspectives, 107(suppl 1), pp.71-80. (Web Link)

[4] Paraoxonase status and plasma butyrylcholinesterase activity in chlorpyrifos manufacturing workers

James W Albers, David H Garabrant, Stanley Berent & Rudy J Richardson

Journal of Exposure Science and Environmental Epidemiology volume 20, pages 79–89 (2010) (Web Link)

[5] Adeshina, Y. A., Solomon, A. and Ademola, A. F. (2019) “Contamination Levels of Organochlorine and Organophosphorous Pesticide Residues in Water and Sediment from River Owena, Nigeria”, Current Journal of Applied Science and Technology, 34(2), pp. 1-11. doi: 10.9734/cjast/2019/v34i230119. (Web Link)

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