News Update on Adiponectin Research: Aug – 2019

Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity

We isolated the human adipose-specific and most teeming cistron transcript, apM1 (Maeda, K., et al.,Biochem. Biophys. Res. Commun.221, 286–289, 1996). The apM1 cistron product was a form of soluble matrix macromolecule, that we tend to named adiponectin. To quantitate the plasma adiponectin concentration, we’ve created being ANd polyclonal antibodies for human adiponectin and developed an enzyme-linked immunosorbent assay (ELISA) system. Adiponectin was copiously gift within the plasma of healthy volunteers within the vary from one.9 to 17.0 mg/ml. Plasma concentrations of adiponectin in corpulent subjects were considerably not up to those in non-obese subjects, though adiponectin is secreted solely from fatty tissue. The ELISA system developed during this study are helpful for elucidating the physiological and pathophysiological role of adiponectin in humans.  [1]

Adiponectin and Adiponectin Receptors

Metabolic syndrome is believed to result from fat and obesity-linked hormone resistance. fat in adulthood is characterised by adipocyte hypertrophy. fat participates within the regulation of energy equilibrium as a crucial endocrine organ that secretes variety of biologically active “adipokines.”  [2]

Adiponectin and Metabolic Syndrome

In this critique, the crucial roles of adipocytes within the development of questionable metabolic syndrome and vascular  illness are reviewed, specializing in adipocyte-derived bioactive substances, adipocytokines. Recent progress in adipocyte biology shows that adipocytes aren’t simply anabolic cells however that they secrete a spread of hormones cytokines, growth factors, and alternative bioactive substances. [3]

Adrenergic stimulation of adiponectin secretion in visceral mouse adipocytes is blunted in high-fat diet induced obesity

The secretion adiponectin is secreted by white adipocytes and has been proposes as a key intermediator of obesity-linked endocrine resistance and also the metabolic syndrome. though adiponectin was discovered twenty years past, the data regarding the molecular and cellular regulation of its secretion is incomplete. Here we’ve got investigated the adrenergic regulation of adiponectin secretion in primary visceral (gonadal) adipocytes isolated from lean or obese/diabetic mice. we have a tendency to show that visceral adipocyte adiponectin unleash is triggered by cAMP/catecholamines via signalling pathways involving adrenergic beta-3-receptors (β3ARs) and Exchange macromolecule directly Activated by cAMP, isoform one (Epac1). [4]

Recent Advances in the Understanding of Adiponectin and Its Role in the Aetiology and Pathogenesis of Childhood Obesity

Obesity could be a up to date sickness of epidemic proportions per national and international reports, thought of because the consequence of consumerism and life vogue modifications, that is each true for developed in addition as developing countries. many reports have shown that 30-35% of the population in developed countries is weighty or overweight. varied studies have reportable the etiology and pathologic process of fatness, underneath the doable molecular mechanisms of this condition. one among the most molecules studied is adiponectin, thought of as a key adipokine. this work tries to review this information on adiponectin and its participation within the etiology and pathologic process of childhood fatness. [5]

Reference

[1] Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K. and Kuriyama, H., 1999. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochemical and biophysical research communications, 257(1), pp.79-83. (Web Link)

[2] Kadowaki, T., Yamauchi, T., Kubota, N., Hara, K., Ueki, K. and Tobe, K., 2006. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. The Journal of clinical investigation, 116(7), pp.1784-1792. (Web Link)

[3] Matsuzawa, Y., Funahashi, T., Kihara, S. and Shimomura, I., 2004. Adiponectin and metabolic syndrome. Arteriosclerosis, thrombosis, and vascular biology, 24(1), pp.29-33. (Web Link)

[4] Adrenergic stimulation of adiponectin secretion in visceral mouse adipocytes is blunted in high-fat diet induced obesity

Saliha Musovic & Charlotta S. Olofsson

Scientific Reportsvolume 9, Article number: 10680 (2019) (Web Link)

[5] Theodorakidou, M., Nikola, O.-A. and Lambrou, G. I. (2018) “Recent Advances in the Understanding of Adiponectin and Its Role in the Aetiology and Pathogenesis of Childhood Obesity”, Journal of Advances in Medicine and Medical Research, 25(11), pp. 1-19. doi: 10.9734/JAMMR/2018/38438. (Web Link)

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