New Microchip Sorts White Blood Cells From Whole Blood

Early in 2012, university scientists according to on the event of a postage stamp-sized semiconductor device capable of sorting cells through a way referred to as cell rolling, that mimics a natural mechanism within the body. The device with success separated leukemia cells from cell cultures — however, couldn’t extract cells directly from blood.

Now the cluster has developed a brand new semiconductor device that may quickly separate white blood cells from samples of blood, eliminating any preliminary process steps — which may be tough to integrate into point-of-care medical devices. The hope, the researchers say, is to integrate the semiconductor device into a transportable diagnostic device that will be wont to directly analyze patient blood samples for signs of disease corresponding to infection — notably in regions of developing countries wherever diagnostic research laboratory instrumentality isn’t pronto obtainable. [1]

Titanium oxide nanoparticles fabrication, hemoglobin interaction, white blood cells cytotoxicity, and antibacterial studies

This study is concentrated on the fabrication and characterization of pigment (TiO2) NPs. Afterward; the interaction of TiO2 NPs with human Hb (Hb) was investigated by FTIR spectrometry, light spectrometry, and molecular arrival studies. Also, the cytotoxic result of fancied TiO2 NPs against human white blood cells (WBCs) was thought of by MTT assay. The medicinal drug result of synthesized NPs was examined on genus Pseudomonas aeruginosa (ATCC 27853); Escherichia (ATCC 25922) and cocci aureus (ATCC 25923). TEM and DLS investigations showed that the synthesized TiO2 NPs have a slender nano-sized distribution. XRD pattern of the fancied NPs exhibited that the TiO2 NPs contain anatase section. A similarity inorganic compound I and II signal intensities showed that secondary structure of the adsorbate hemoglobin is preserved. The intrinsic light study discovered that the light extinguishing of hemoglobin was done by complicated formation between hemoglobin and TiO2 NPs through the chemical bond and van der Waals interactions. [2]

Recognizing white blood cells with local image descriptors

Automatic and reliable classification of pictures of white blood cells is fascinating for cheap, fast and correct health designation worldwide. In distinction to previous approaches that tend to believe image segmentation and a careful alternative of circumstantial (geometric) options, we tend to explore the probabilities of native image descriptors, since they’re a straightforward approach they need no express segmentation, and nonetheless they need being shown to be quite strong against background distraction in an exceeding variety of visual tasks. Despite its potential, this technique remains unknown for this downside. during this work, pictures area unit so characterized with the well-known visual bag-of-words approach. 3 key point detectors and 5 regular sampling methods area unit studied and compared. [3]

Flow cytometry for assessment of white blood cells subsets in standard buffy coat product

Circulating white blood cells (WBC) play a vital role within the human system together with each the innate and adaptative immunity. The immune cells corresponding to granulocytes (neutrophils, eosinophils, basophils), lymphocytes, and monocytes area unit often found in blood elements referred to as Buffy Coat. Most of the time the buffy coat serves no clinical purpose since the targeted immune cells (especially the lymphocytes) will trigger the transfusion-associated graft versus the host diseases (TA-GVHD). In special circumstances, corresponding to leucopenia patients undergoing therapy or hematogenic vegetative cell transplant (HSCT) with uncontrolled infection, patients need granulocytes transfusion to atone for the deficiency within the body munition. However, several of in vitro analysis studies need the employment of peripheral blood mononuclear cell (PBMC) for the study of the human system. this will be created doable by uninflected the buffy coat. however, the precise proportion of varied immune cells at intervals the buffy coat particularly among Chinese donors remains unknown. [4]

Changes in White Blood Cells Differential Associated with Adult Malaria-Infected Patients

Aims: protozoal infection parasites square measure expected to impact the white vegetative cell differential of protozoal infection patients, however, reports on changes in white vegetative cell differentials of protozoal infection patients don’t seem to be well documented, thence this study was undertaken to work out changes in white vegetative cell differentials related to male and feminine protozoal infection patients.

Study Design: Twenty male and twenty feminine protozoal infection patients were divided into four teams created from 10 protozoal infection positive males (MPM), 10 protozoal infection negative males (MNM), 10 protozoal infection positive females (MPF) and 10 protozoal infection negative females (MNF).

Methodology: The hematological parameters were evaluated victimization machine-driven descent count Sysmex machine. [5]

Reference

[1] New Microchip Sorts White Blood Cells From Whole Blood

(web link)

[2] Titanium oxide nanoparticles fabrication, hemoglobin interaction, white blood cells cytotoxicity, and antibacterial studies

Abdlomajid E, Kharazi H, Chalaki M, Khojasteh M, Haghighat S, Attar F, Nemati F, Falahati M. Titanium oxide nanoparticles fabrication, hemoglobin interaction, white blood cells cytotoxicity, and antibacterial studies. Journal of Biomolecular Structure and Dynamics. 2018 Jul 13(just-accepted):1-38. (web link)

[3] Recognizing white blood cells with local image descriptors

López-Puigdollers D, Traver VJ, Pla F. Recognizing white blood cells with local image descriptors. Expert Systems with Applications. 2018 Aug 21. (web link)

[4] Flow cytometry for assessment of white blood cells subsets in standard buffy coat product

Ho SN. Flow cytometry for assessment of white blood cells subsets in standard buffy coat product. HKU Theses Online (HKUTO). 2017. (web link)

[5] Changes in White Blood Cells Differential Associated with Adult Malaria-Infected Patients

J. C. Ozougwu1*

1Department of Biological Sciences, College of Basic and Applied Sciences, Rhema University, Aba, Abia State, Nigeria. (web link)

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