Common Hypertension Drug Shows Promise Against Parkinson’s Disease

A new study suggests that a typical high blood pressure drug could provide a more practical thanks to treating Parkinson’s. A run-down supermolecule inflicting cyanogenic clumps to create within the brains of Parkinson’s unwellness patients additionally causes immune cells to trigger inflammation, the study has disclosed, which implies a drug already approved to treat high blood pressure could provide a more practical treatment.. [1]

Design of a randomized controlled trial comparing a mobile phone-based hypertension health coaching application to home blood pressure monitoring alone: The Smart Hypertension Control Study

Background: high blood pressure may be a major reason behind morbidity and mortality however often remains uncontrolled. A smartphone application that gives work relating to home pressure watching and alternative aspects of high blood pressure self-care and connected behavior amendment is also ascendible thanks to facilitating manage high blood pressure.

Methods/design: The sensible high blood pressure management Study may be a prospective, irregular controlled trial. it’ll assess the results of a high blood pressure personal management program (HPCP), that consists of an automatic AI smartphone application that gives personalized support and training, to market home watching and healthy behavior changes involving high blood pressure self-management at the side of home pressure watching compared to home pressure watching alone. registered adults with uncontrolled high blood pressure are irregular during a 1:1 fashion to the HPCP with home pressure watching or to home watching alone. we tend to conceive to recruit 350 participants, with a target of three hundred participants with complete six-month follow-up information. the first study outcome is pulse pressure at six months. extra outcomes embrace measures of medicament medication adherence, home pressure watching practices, self-management practices, weight, and self-reported health behaviors. [2]

Moderate-intensity exercise and renin-angiotensin system blockade improve renovascular hypertension (2K1C)-induced gastric dysmotility in rats

Actually, blood vessel cardiovascular disease could be a major public health concern, that involves the proteolytic enzyme angiotonin mineralocorticoid system (RAS), via activation of the angiotonin receptors AT1 and AT2 of the circulatory system. though angiotonin is a very important stimulant of the gut porosity to metallic element and water, very little is understood concerning the results of blood vessel cardiovascular disease on gut motor behavior. Thus, we have a tendency to evaluated in rats the result of cardiovascular disease evoked by two-kidney one-clip (2K1C) model on the internal organ motility, similarly because of the influence of exercise and RAS blockers treatment in such development. One week after surgery the rats were treated with Aliskiren (50 mg•kg−1, p.o.), Captopril (50 mg•kg−1, p.o.) or Losartan (10 mg•kg−1, p.o). an alternative cluster of rats was submitted to swimming with five-hitter weight overload. After 4 weeks of physical training or pharmacological treatment, we have a tendency to assessed the internal organ retention all told teams (GR) of a liquid take a look at meal, the mean blood pressure (MAP), the center rate (HR) and also the 60 minutes variation (HRV) similarly because the in vitro ability of internal organ bodily structure. Renovascular hypertension increased (p < 0.05) the GR, MAP and HR, a development prevented by pretreatment with RAS blockers or exercise. The two kidney one-clip Hypertension (2K1C) decreased (p < 0.05) the internal organ bodily structure responsiveness, a development conjointly prevented by exercise. It conclusion, renovascular cardiovascular disease delays the internal organ voidance of liquids, a development involving the activation of RAS, wherever exercise or blockade with aliskiren, ACE inhibitor and losartan stop internal organ dysmotility. [3]

Correlation of native T1 mapping with right ventricular function and pulmonary hemodynamics in patients with chronic thromboembolic pulmonary hypertension before and after balloon pulmonary angioplasty

Objectives: The aim of this study was to assess native T1 mapping in patients with inoperable chronic thromboembolic respiratory organ cardiovascular disease (CTEPH) before and half-dozen months when balloon respiratory organ operation (BPA) and compare the results with right heart operate and respiratory organ hemodynamics.

Methods: resonance imaging at one.5 T and right heart catheterization were performed in twenty-one consecutive inoperable CTEPH patients before and half-dozen months when BPA. T1 values were measured among the body part heart muscle, the higher and lower right bodily cavity insertion points, and also the lateral wall at the basal short-axis section. additionally, the area-adjusted body part native T1 time (AA-T1) was calculated and compared with right bodily cavity operate (RVEF), mean respiratory organ blood pressure (mPAP) and respiratory organ vascular resistance (PVR). [4]

Knowledge of Hypertension and other Risk Factors for Heart Disease among Yoruba Rural Southwestern Nigerian Population

 Background and Objectives: there’s a dearth of reliable data on information concerning high blood pressure and upset (CVD) risk factors in rural southwestern Federal Republic of Nigeria. This study assessed the amount of awareness, basic information, and management of high blood pressure and CV risk factors among individuals living in the rural southwestern Federal Republic of Nigeria.

Methods: A population primarily based cross-sectional survey was conducted in Egbeda regime space of Oyo State, Nigeria. A structured form was accustomed interview 2000 subjects so as to assess information on assorted aspects of modifiable CV risk factors.

Results: the most common supply of medical data was the family/friend/opinion leaders of trusty teams in 1198(59.9%), the media (including radio, public enlightenment programmes, and newspapers) in 492(24.6%), and therefore the doctor/nurse/health employee in 183(9.1%) of the respondents. the information on CVD and its risk factors was poor. concerning fifty-six of the respondents couldn’t determine one risk issue. of this UN agency were able to, solely a number of may properly determine the connection between CV risk factors and CVD with some misconceptions. we have a tendency to found that subjects UN agency had a lot of years of formal education, a positive case history of CVD, and self-rumored history of DM were a lot of doubtless to possess a decent level of data of high blood pressure and different CV risks once adjusted for age, gender, and legal status. [5]

References

[1] Common Hypertension Drug Shows Promise Against Parkinson’s Disease

KATIE SILVER, 26 MAY 2015 (Web link)

[2] Design of a randomized controlled trial comparing a mobile phone-based hypertension health coaching application to home blood pressure monitoring alone: The Smart Hypertension Control Study

Persell SD, Karmali KN, Stein N, Li J, Peprah YA, Lipiszko D, Ciolino JD, Sato H. Design of a randomized controlled trial comparing a mobile phone-based hypertension health coaching application to home blood pressure monitoring alone: The Smart Hypertension Control Study. Contemporary Clinical Trials. 2018 Aug 29. (Web link)

[3] Moderate-intensity exercise and renin-angiotensin system blockade improve renovascular hypertension (2K1C)-induced gastric dysmotility in rats

de Sousa Lima EB, de Oliveira LC, da Silva Cardoso G, Teles PV, da Costa Lima L, e Sousa JF, Araújo RP, de Oliveira AP, dos Santos RF, dos Santos AA, da Silva MT. Moderate-intensity exercise and renin-angiotensin system blockade improve renovascular hypertension (2K1C)-induced gastric dysmotility in rats. Life Sciences. 2018 Aug 28. (Web link)

[4] Correlation of native T1 mapping with right ventricular function and pulmonary hemodynamics in patients with chronic thromboembolic pulmonary hypertension before and after balloon pulmonary angioplasty

Roller FC, Kriechbaum S, Breithecker A, Liebetrau C, Haas M, Schneider C, Rolf A, Guth S, Mayer E, Hamm C, Krombach GA. Correlation of native T1 mapping with right ventricular function and pulmonary hemodynamics in patients with chronic thromboembolic pulmonary hypertension before and after balloon pulmonary angioplasty. European Radiology. 2018:1-9. (Web link)

[5] Knowledge of Hypertension and other Risk Factors for Heart Disease among Yoruba Rural Southwestern Nigerian Population

  1. O. Oladapo1,2*, L. Salako3, L. Sadiq 4, K. Soyinka5 and A. O. Falase1

1Cardiovascular Unit, Department of Medicine, University College Hospital, College of Medicine, University of Ibadan, Nigeria;

2Department of Anatomy, College of Medicine, University of Ibadan, Nigeria.

3University of Ibadan, Nigeria.

4Country office, World Health Organization, Lagos, Nigeria.

5Primary Health Egbeda Local Government, Oyo State, Nigeria. (Web link)

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