Tissue engineering is a growing multidisciplinary area that tries to regenerate, enhance, or replace predicted damaged or missing tissues for a variety of disorders caused by trauma, disease, and ageing. To ensure that tissue engineering procedures are extensively used in clinical practise, they must be modified so that they are readily available and reasonably simple to utilise in regular clinical practise. To make realistic implementation, the steps between preparation and application must be minimised and optimised. The overall goal is to develop natural platelet concentrates that can be manufactured near to the patient and speed up the implantation procedure while remaining financially feasible for both the patient and the health system. For soft tissue regeneration, fibrin rich in platelets and leukocytes (PRF) and its derivatives (L-PRF, A-PRF, i-PRF) have been employed in a range of medical sectors. In groups evaluated following PRF membrane extraction, almost all platelets (> 97%) are missing from test tubes.
Other cell types involved in tissue repair, such as smooth cell muscles (SMCs) and mesenchymal stem cells, are induced and controlled by growth factors released by platelets found in derivatives of L-PRF (MSCs).
Finally, the findings of this study show that PRF has a good influence on wound healing following surgery.
Department of Medicine, Surgery and Dentistry “Salernitan Medical School”, University of Salerno, Fisciano (SA), Italy and United of Derma Surgery, Skin Transplants and Difficult Wounds, “Villa Fiorita” Nursing Home, Aversa (CE), Italy.
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