Metalloenzymes for the Potent Treatment of Alzheimer’s Disease and Parkinson’s Disease: A Review


There has been hypothesis that various amyloidogenic proteins assume a part in the beginning and movement of neurodegenerative illnesses (ND), including Parkinson’s sickness and Alzheimer’s sickness (PD). Various little mixtures have been made to control the accumulation cycles of these amyloid proteins in endeavor to treat the issues. As well as controlling the collection of amyloidogenic protiens, keeping up with the levels of the proteins in the cerebrum by amyloid debasing catalysts [ADE; neprilysin (NEP), insulin corrupting chemical (IDE), asparagine endopeptidase (AEP), and ADAM10] is crucial for fix AD and PD. Hence, various natural atoms and substance specialists have been analyzed if they would go about as inducers or inhibitors against the levels and exercises of ADE. Albeit the expulsion of amyloidogenic proteins by expanding the movement of ADE might have the potentially negative side-effect aftereffects, it might bring about a somewhat decent procedure for treating AD and PD. Moreover, since the reasons for ND are different, various multi-utilitarian (multi-target) synthetic specialists have been created to control the activities of numerous ND risk factors, for example, amyloidogenic proteins, metal particles, and responsive oxygen species. In any case, large numbers of them were formed without considering how to control ADE levels and ways of behaving. A potential way to deal with treating AD and PD would include consolidating recently delivered compounds with drug medicines that treat ADE. In this part, the ADE and mixtures that have some control over the action and articulation of the ADE are presented.

Author(s) Details:

Namdoo Kim,
Department of Chemistry, Kongju National University, Gongju, Chungcheongnam-do 32588, Republic of Korea.

Hyuck Jin Lee,
Department of Chemistry Education, Kongju National University, Gongju, Chungcheongnam-do 32588, Republic of Korea.

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Keywords: Alzheimer’s disease, parkinson’s disease, amyloid degrading enzyme, neprilysin, insulin degrading enzyme, asparagine endopeptidase, ADAM10

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