Mass Intake of Hydroxychloroquine or Chloroquine during Covid-19 Pandemic: Possible Consequences in Endemic Malaria Settings

The world is currently experiencing a new pandemic for which there is no cure. Coronavirus disease 2019 (Covid-19) has infected 183 countries and killed a large number of people. Many reports cited chloroquine (CQ) and hydroxychloroquine (HCQ), two former malaria drugs, as the best current option for combating this dreadful disease. Because these molecules were removed from malaria treatment policies due to chemoresistance, their reintroduction could have some ramifications. Though local malaria prevalence may decrease for a time, molecular changes in some plasmodium falciparum genes involved in drug resistance are likely. If these molecules are widely distributed, This could jeopardize malaria control efforts if it is administered.

Author (S) Details

Dr. Dieudonné M. Mvumbi
Biochemistry and Molecular Biology Unit, Department of Basic Sciences, School of Medicine, University of Kinshasa, BP 190 KIN XI, Kinshasa, DR Congo.

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