Managing the Risks Associated with Pregnancy in Epileptic Women
In most epileptic women, a normal pregnancy is expected (WWE). The key to a favourable maternal outcome in WWE is pre-pregnancy counselling that focuses on teaching the patient about her disease and treating her seizures with the most suitable and lowest feasible dose of Anti-Epileptic Drug (AED). A joint epilepsy obstetric clinic should ideally provide prenatal care. When data from epileptic pregnancy registers from multiple national registers is analysed, it becomes clear that newer AEDs like lamotrigine and levetiracetam are linked to a lower risk of significant congenital anomalies. malformations. Sodium valproate and topiramate appear to reduce the risk of serious congenital deformity and should only be used in WWE of reproductive age if other AEDs have failed to control seizures. In WWE management, lamotrigine and levetiracetam have become first-line medications. Although further trials with a greater number of cases are required to confirm the findings. The objective of this article is to provide an update on WWE’s pre- and post-pregnancy management. The article discusses the frequency of seizures in pregnancy, the impact of epileptic seizures on the foetus, the occurrence of difficulties throughout pregnancy and delivery, and the incidence of foetus death. The prevalence of foetal congenital abnormalities, their impact on intrauterine growth, and the developmental and behavioural outcomes of infants are all factors to consider.
Author (s) Details
Dr. Mamta Mahajan
Department of Gynecology, Dr RPGMC, Tanda, Kangra, Himachal Pradesh, India.
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