Latest News on Emblica Officinalis Research: Oct – 2019

Antioxidant activity of active tannoid principles of Emblica officinalis (amla)

The inhibitor activity of tannoid active principles of E. officinalis consisting of emblicanin A (37%), emblicanin B (33%), punigluconin (12%) and pedunculagin (14%), was investigated on the premise of their effects on rat brain frontal animal tissue and striatal concentrations of the aerophilic radical scavenging enzymes, SOD (SOD), enzyme (CAT) and antioxidant (GPX), and lipide peroxidation, in terms of thiobarbituric acid-reactive merchandise. The results were’ compared with effects induced  by deprenyl, a selective MAO (MAO) B matter with well documented inhibitor activity. The active tannoids of E. officinalis (EOT), administered within the doses of five and ten mg/kg. i.p .. and deprenyl (2 mg/kg, i.p.), induced  a rise in each frontal animal tissue and striatal SOD, CAT and GPX activity, with concomitant decrease in lipide peroxidation in these brain areas once administered once daily for seven days. [1]

Biosynthesis of Gold and Silver Nanoparticles Using Emblica Officinalis Fruit Extract, Their Phase Transfer and Transmetallation in an Organic Solution

The design, synthesis and characterization of biologically synthesized nanomaterials became a neighborhood of great interest. during this paper, we tend to report the living thing synthesis of gold and silver nanoparticles victimization Emblica Officinalis (amla, Indian Gooseberry) fruit extract because the reducer to synthesize silver and Au nanoparticles, their later section transfer to Associate in Nursing organic answer and therefore the transmetallation reaction of hydrophobized silver nanoparticles with hydrophobized chloroaurate ions. On treating liquid silver sulphate and chloroauric acid solutions with Emblica Officinalis fruit extract, speedy reduction of the silver and chloroaurate ions is ascertained resulting in the formation of extremely stable silver and gold nanoparticles in answer. Transmission microscopy analysis of the silver and gold nanoparticles indicated that they ranged in size from ten to twenty nm and fifteen to twenty five nm severally. [2]

Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis

Extracts of Emblica officinalis (EO), Phyllanthus amarus (P. amarus) and Picrorrhiza kurroa (P. kurroa) considerably inhibited  hepatocarcinogenesis induced  by N-nitrosodiethylamine (NDEA) in an exceedingly dose dependent manner. The anticarcinogenic activity of those extracts were evaluated by their result on neoplasm incidence, levels of matter metabolizing enzymes, levels of carcinoma markers and liver injury markers. Animals treated with NDEA alone showed 100 percent neoplasm incidence and considerably elevated tissue levels of drug metabolizing enzymes like glutathione S-transferase (GST) and aminoalkane hydroxylase (AH). Treatment of extracts considerably reduced these levels. Levels of γ-glutamyl transpeptidase (GGT) were additionally found to be elevated each in blood serum and tissues of neoplasm bearing animals, whereas they were considerably reduced within the treated cluster. [3]

Dietary chemoprevention of clastogenic effects of 3,4-benzo(a)pyrene by Emblica officinalis Gaertn. fruit extract

Dietary supplementation with extract of fruit of Emblica officinalis Gaertn. (a made supply of nutriment C) to mice in vivo considerably reduced the cytotoxic effects of a well-known matter, 3,4-benzo(a)pyrene. Age-matched Swiss unusual person mice were fed by gavaging the fruit extract daily for twenty eight days. From day 9, one dose of the matter was given on alternate days up to a complete of eight doses. On day 29, all mice were transferred to traditional diet. management sets received the extract alone, the matter alone and vegetable oil alone. All mice were sacrificed at twelve weeks and fourteen weeks once the tip of the experiment. body preparations were made up of bone marrow once the standard colchicine-hypotonic-fixative-air drying-Giemsa staining schedule. [4]

Healing Role of Guduchi [Tinospora cordifolia (Willd.) Miers] and Amalaki (Emblica officinalis Gaertn.) Capsules in Premature Aging Due to Stress: A Comparative Open Clinical Trial

Aims: to search out out the comparative effects of the capsules ready from the medicine Guduchi [Tinospora cordifolia (Willd.) Miers] and Amalaki (Emblica officinalis Gaertn.) in cases of premature aging thanks to stress.

Study Design: Comparative open run.

Place and length of Study: IPD and OPD of National Institute of written material and Seth Soorajmal Bombawala Hospital, Jaipur, Rajasthan, India, between Gregorian calendar month 2016 and Gregorian calendar month 2017.

Methodology: we have a tendency to enclosed thirty patients (14 men, sixteen women; age vary 25-60 years) with premature aging thanks to stress, with none different acute or serious general disorders. They were indiscriminately divided in 3 teams with ten patients in every. cluster A- was treated with capsule of Guduchi one gm/day, cluster B–capsule of Amalaki one gm/day and cluster C- was treated with 500mg capsules of Guduchi and Amalaki singly once daily for three months. Visual Analogue Scale and Stress were assessed by Hamilton Anxiety Rating Scale (HARS). Objective parameters like blood profile, CRP, FBS, Blood Urea, creatinine, SGOT, SGPT and humor cholesterin were additionally analysed. [5]

Reference

[1] Bhattacharya, A., Chatterjee, A., Ghosal, S. and Bhattacharya, S.K., 1999. Antioxidant activity of active tannoid principles of Emblica officinalis (amla). (Web Link)

[2] Ankamwar, B., Damle, C., Ahmad, A. and Sastry, M., 2005. Biosynthesis of gold and silver nanoparticles using Emblica officinalis fruit extract, their phase transfer and transmetallation in an organic solution. Journal of nanoscience and nanotechnology, 5(10), (Web Link)

[3] Jeena, K.J., Joy, K.L. and Kuttan, R., 1999. Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis. Cancer Letters, 136(1), (Web Link)

[4] Dietary chemoprevention of clastogenic effects of 3,4-benzo(a)pyrene by Emblica officinalis Gaertn. fruit extract
P Nandi, G Talukder & A Sharma
British Journal of Cancer volume 76, (Web Link)

[5] Pal, S., Ramamurthy, A., Rath, S. and Mahajon, B. (2017) “Healing Role of Guduchi [Tinospora cordifolia (Willd.) Miers] and Amalaki (Emblica officinalis Gaertn.) Capsules in Premature Aging Due to Stress: A Comparative Open Clinical Trial”, European Journal of Medicinal Plants, 21(2), (Web Link)

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