Investigating the Enhancement of Solubility of Poorly Water-Soluble Drugs Diclofenac Sodium by Mixed Solvency Approach

Increasing solubility is one of the challenging issues that arises during the formulation development of an orally delivered medication with poor water solubility. Drugs with low water solubility have a difficult difficulty creating formulations with sufficient bioavailability, which prevents them from being utilised successfully. The phenomenon of improving the solubility of poorly water-soluble pharmaceuticals in an aqueous solution containing blends of hydrotropic agents, co-solvents, and water-soluble solutes that may have a synergistic effect on drug solubility is referred to as “mixed-solvency.” A mixed solvency approach was used in this study to improve the aqueous solubility of the poorly water-soluble drug diclofenec sodium (selected as a model drug) by combining a variety of water-soluble substances from the hydrotropic (urea, sodium acetate); water soluble solutes (PEG4000, PEG6000); and co-solvents (PEG200, PEG400). The aqueous solubility of diclofenac sodium was measured at room temperature in randomly selected blends of solubilizers having various combinations while maintaining a total concentration of 50% w/v. Diclofenec sodium has a maximum wavelength of 276 nm and follows Beers Law in the concentration range of 10-60 g/ml. The results show that by utilising a mixed solvency technique, the solubility of diclofenac sodium-containing blends of various combinations was greatly improved.

Author(S) Details

Masheer Ahmed Khan
School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshshila Campus, Khandwa Road, Indore-452001, India.

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