Increasing solubility is one of the challenging issues that arises during the formulation development of an orally delivered medication with poor water solubility. Drugs with low water solubility have a difficult difficulty creating formulations with sufficient bioavailability, which prevents them from being utilised successfully. The phenomenon of improving the solubility of poorly water-soluble pharmaceuticals in an aqueous solution containing blends of hydrotropic agents, co-solvents, and water-soluble solutes that may have a synergistic effect on drug solubility is referred to as “mixed-solvency.” A mixed solvency approach was used in this study to improve the aqueous solubility of the poorly water-soluble drug diclofenec sodium (selected as a model drug) by combining a variety of water-soluble substances from the hydrotropic (urea, sodium acetate); water soluble solutes (PEG4000, PEG6000); and co-solvents (PEG200, PEG400). The aqueous solubility of diclofenac sodium was measured at room temperature in randomly selected blends of solubilizers having various combinations while maintaining a total concentration of 50% w/v. Diclofenec sodium has a maximum wavelength of 276 nm and follows Beers Law in the concentration range of 10-60 g/ml. The results show that by utilising a mixed solvency technique, the solubility of diclofenac sodium-containing blends of various combinations was greatly improved.
Masheer Ahmed Khan
School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshshila Campus, Khandwa Road, Indore-452001, India.
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