Using the Randomized Complete Block Design (RCBD) using albino mice as test animals, the anti-diabetic action of Leucaena leucocephala Linn. (Ipil-ipil) seed extract was demonstrated. The researchers also wished to identify the phytochemicals in the extract, as well as assess its physical properties and compare its effects at three concentration levels to a positive control, a commercially available anti-hyperglycemic medicine. The extract contained alkaloid, flavonoid, saponin, tannin, and phenolic components, but no anthraquinone or steroid. The extract was orange in colour, tasted good, had a pH of 5.44, and was miscible in water and acetone but not chloroform. The extract with a 50 percent concentration was found to be the most effective in reducing blood glucose levels (BGL) in the experimental animals, whereas the pure extract with a 100 percent concentration was found to be the least effective. However, there were no notable variations in terms of Between the concentration levels and the commercial medicine, BGL decreases. As a result, the anti-diabetic activities of Leucaena leucocephala Linn are comparable to those of the commercial anti-hyperglycemic medicine Metformin. Additional plant parts should be studied for anti-diabetic potential, taking into account the identification of other secondary metabolites that may be present in plant components, as well as other potential applications.
Author (S) Details
Elchin R. Juanico
Department of Biological Sciences, College of Science, University of Eastern Philippines, University Town, Northern Samar, Philippines.
Abel Alejandro U. Flores
Department of Biological Sciences, College of Science, University of Eastern Philippines, University Town, Northern Samar, Philippines and University Research and Development Services, University of Eastern Philippines, University Town, Northern Samar, Philippines.
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