Investigating on the Effect of Calendula officinalis Leaf Extract on Excision Wound Healing in Swiss albino Mice


One of those plants, Calendula officinalis, has medical value since both its leaves and flowers exhibit pharmacological activity. However, less attention has been paid to crucial pharmacological parameters, which can be demonstrated scientifically by reverse pharmacology. An annual herb with Mediterranean origin called calendula officinalis is widely used as an anti-inflammatory and for wound healing. It was thought to be interesting to assess these qualities of the Calendula officinalis leaf extract. The ability of gels made from methanolic extracts of Calendula officinalis Linn to treat wounds was tested using excision wound models in albino mice. Carbopol gels were used to generate extract formulations both separately and in combination in an equal ratio. Excision wound models showed that the treated animals’ epithelization time and wound healing activities were significantly reduced. The enhanced free radical scavenging ability and phytoconstituents present in hydro alcoholic extracts, which, either alone or in combination, promote wound healing, may be responsible for the extracts’ improved wound healing activity. Increased connective tissue synthesis, especially collagen production, is evidence that calendula extract boosted wound healing activity. The granuloma tissue has greatly expanded. It was shown that the increased tensile strength and wound contraction were statistically significant.

Author(s) Details:

Priyanka Pandey,
School of Studies in Chemical and Biological Sciences, MATS University, Raipur – 492001, Chhattisgarh, India.

Wasim Raja,
Central Laboratory Facility, Chhattisgarh Council of Science and Technology, Raipur- 492014, Chhattisgarh, India.

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Keywords: Calendula officinalis, wound healing activity, methanolic extracts, epithelization, merigold and gel

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