Inhibitory Effect of Compounds Isolated from the Aerial Part of Piper bavinum on Nitric Oxide Production

Nitric group of chemical elements (NO) is a major product and allure production is conditional nitric oxide synthases (NOSs), which involve inducible nitric oxide synthases (iNOS). The inundation of NO by iNOS regulation has been engaging attention the pathology of various inflammatory disorders, including poisonous shock, tissue damage, and rheumatoid arthritis. NO production inferred by lipopolysaccharide (LPS) through iNOS can reflect the quality of inflammation. This study reports the anti-instigative activity of isolated compounds from Piper bavinum C.CD. (Piperaceae). Eight subordinate metabolites (1-8) have been private from the aerial part of P. bavinum. The synthetic structures of 1-8 were established primarily by NMR and mass spectra. Compound 5 was private from P. bavinum for the first time. The antagonistic-inflammatory activity of the unique compounds was evaluated against lipopolysaccharide (LPS)-induced nitric group of chemical elements (NO) production in RAW264.7 containers in vitro. Compound 4 inhibited LPS-inferred NO production the most efficiently, with an ic50 worth of 5.2 M, followed by compound 5, which shy NO production with an ic 50 profit of 13.5 M. Compound 4 suppressed LPS-induced COX-2 and iNOS verbalization in a dose-contingent manner at the protein level. The findings submitted that P. bavinum and its constituents concede possibility have anti-instigative properties.

Author(s) Details:

Nguyen Thi Ai Nhung,
Department of Chemistry, University of Sciences, Hue University, Hue City, 530000, Vietnam.

Hoang Viet Dung,
Vietnam Military Medical University, 160 Phung Hung Street, Hadong District, Hanoi 151000, Vietnam.

Tran Thi Ai My,
Department of Chemistry, University of Sciences, Hue University, Hue City, 530000, Vietnam.

Phan Tu Quy,
Department of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak 630000, Vietnam.

Dao-Cuong To,
Phenikaa University Nano Institute (PHENA), Phenikaa University, Yen Nghia, Ha Dong District, Hanoi 12116, Vietnam and Phenikaa Research and Technology Institute (PRATI), A&A Green Phoenix Group JSC, 167 Hoang Ngan, Cau Giay District, Hanoi 11313, Vietnam.

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Keywords: Piper bavinum, inflammation, NO production, cytotoxic, RAW264.7 cells

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