In-vitro Bioactivity of Herbal Mixture Curcuma longa Linn, Cissus quadrangularis and Boerhaavia diffusa – An In vitro Study

 

Plants are crucial in the creation of medications, and the pharmaceutical industry relies heavily on natural ingredients to create new treatments. Curcumin is a natural compound found in the rhizomes of the plants Curcuma longa Linn, Cissus quadrangularis L., and Boerhaavia diffusa L. Curcumin is a natural compound found in the rhizomes of the plants Curcuma longa Linn, Cissus quadrangularis L., and Boerhaavia diffusa L. Curcumin is a natural compound found in the rhizomes of the plant.

The goal of this study is to see if the aqua-alcoholic extract of the herbal mixture (Curcuma longa Linn + Cissus quadrangularis + Boerhaavia diffusa) has any cytotoxic, antioxidant, thrombolytic, antiinflammatory, or antibacterial activities.

Curcuma longa Linn, Cissus quadrangularis, and Boerhaavia diffusa were combined to make an aqua-alcoholic extract. Phytochemical in-vitro studies using the CCB mixture included cytotoxicity using the brine shrimp lethality assay, antioxidant activity using the DPPH assay, anti-inflammatory activity using the albumin denaturation assay, antimicrobial activity using the agar well diffusion method against Staphylococcus aureus, Streptococcus mutans, Escherichia coli, and Candida albicans, and thrombolytic activity using the clo.

The CCB mixture showed excellent cytotoxic activity at various concentrations in a brine shrimp lethality assay, boosting antioxidant activity with DPPH assay, increasing thrombolytic activity, anti-inflammatory activity, and anti-microbial activity with increasing concentration, but the anti-microbial activity was ineffective as positive controls.

In this in vitro study, the CCB combination showed significant cytotoxic, antioxidant, thrombolytic, anti-inflammatory, and antibacterial activity. More in vivo animal studies and human clinical trials are needed.

Author(s) Details:

Y. Dinesh,
Department of Oral Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, India.

R. Abilasha,
Department of Oral Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, India.

Pratibha Ramani,
Department of Oral Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, India.

S. Rajesh Kumar,
Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, India.

Please see the link here: https://stm.bookpi.org/CAPRV-3/article/view/6952

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