Hepatitis B Virus Infection and MicroRNAs: Future Trends to Diagnostics and Therapeutics


Hepatitis B virus (HBV) infects the liver and causes acute and chronic sickness, which can progress to severe end-stage liver disease. Despite the availability of an effective vaccination and a variety of treatment options, this virus remains the leading cause of liver disease, accounting for a significant portion of global morbidity and death. The significance of miRNAs, which are essential modulators of gene activity, in the control of Hepatitis B virus gene expression has been widely studied. Facilitation, direct or indirect inhibition, immune response activation, epigenetic modulation, and a variety of other mechanisms can all be used to control viral reproduction and pathogenicity. There are certain miRNAs that engage in more than one of these processes among the many miRNAs involved in each of these mechanisms. The current chapter is an attempt to categorise these miRNAs effectively from a functional standpoint. A thorough understanding of miRNAs and their methods for changing the virus and/or the host might aid in the future development of numerous diagnostic and therapeutic techniques. Sarkar et al. published the findings of this chapter in the International Journal of Molecular Sciences in 2015.

Author(S) Details

Neelakshi Sarkar
ICMR Virus Unit, Kolkata, ID & BG Hospital Campus, Kolkata, India

Runu Chakravarty
Virus Unit, Kolkata, ID & BG Hospital Campus, Kolkata, India.

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