Focusing on the Molecular Aspects and New Biochemical Pathways Underlying Ozone Effects

Oxygen and oxidative stress are key factors for all the living matter on our planet. It is obvious that all
the cells of these organisms must be provided of adequate protections either for the control of the
oxygen concentrations or for the excess of the oxidative stress. Thus, it is not surprising that the
Nobel Prize in Physiology or Medicine 2019 was awarded jointly to William G. Kaelin Jr, Sir Peter J.
Ratcliffe and Gregg L. Semenza “for their discoveries of how cells sense and adapt to oxygen
“. No less important is the role of an excess of oxidative stress which could derive from an
imbalance between the production of energy in the mitochondria, with a consequent increase in free
radicals, and the antioxidant capability of our cells. In recent scientific literatures, it is emerging the
possibility that ozone could upregulate the Nrf2 pathway related to the oxidative stress, thus indicating
a rational explanation of its surprising effects induced at low doses in humans. Furthermore, it could
be of paramount importance for the control of the aging process, reducing or ameliorating the
deleterious effects of oxidative stress.

Author (s) Details

Lamberto Re,
Pharmacology Department at the University of Ancona, Italy and The Scientific Advisory Board of WFOT (, Italy and Medinat Clinic, Camerano (, Italy.

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