The goal of this study is to develop and evaluate natural biodegradable zidovudine microcapsules using olibanum resin as a microencapsulating agent, which after oral administration could improve the drug’s bioavailability and provide sustained release, reducing dose-dependent side effects and improving patient compliance. For the manufacture of different batches of microcapsules, an industrially feasible emulsification-solvent evaporation approach was adopted. Particle morphology, microencapsulation efficiency, manufacturing yield, micromeritic characteristics, release profile and release kinetics, and other aspects of the proposed system were examined in vitro. Differential scanning calorimetry, X-ray diffraction, and infrared spectroscopy were used to assess the physical and chemical properties of zidovudine and zidovudine-loaded microcapsules. The microcapsules with resin coatings were found to be spherical, distinct, and free-flowing. The microencapsulation efficiency was within a restricted range (81-88%), implying that medication distribution was consistent between batches. The findings of the thermohram and X-ray diffractogram revealed a partial alteration in the solid state of zidovudine. Depending on the core:coat ratio, zidovudine release from optimised batches of resin coated microcapsules took up to 24 hours. The Fickian diffusion process was discovered to be responsible for drug release. The resin-coated microcapsules had good controlled release properties and were determined to be suitable for a once-daily oral controlled release product.

Author (s) Details

Dr. Satyajit Panda
Department of Pharmaceutics, Institute of Pharmacy and Technology, Salipur, Cuttack (Odisha) – 754202, India.

Snigdha Pattnaik
School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University, Jagmohan Nagar, Jagamara, Bhubaneswar (Odisha), India.

Laxmidhar Maharana
School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University, Jagmohan Nagar, Jagamara, Bhubaneswar (Odisha), India.

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