Early Assessment of the Risk of Developing Subclinical Hypothyroidism and Cardiovascular Risk in Patients with Nonalcoholic Fatty Liver Disease

Background: It is well established that subclinical hypothyroidism (SH) might exacerbate the progression of non-alcoholic fatty liver disease (NAFLD) (NAFLD). NAFLD, in turn, encourages thyroid gland hypofunction. Patients with SH have a higher risk of cardiovascular events, although research on SH screening recommendations is conflicting and inadequate.

The goal of this study was to determine the risk of developing subclinical hypothyroidism (SH) in patients with non-alcoholic fatty liver disease (NAFLD) who had a different risk of cardiovascular complications, as well as the relationship between a high risk of developing SH and major cardiovascular factors (CV). Methods and materials: 298 patients with NAFLD who had one or more CV risk factors (arterial hypertension, smoking, hypercholesterolemia) and different levels of CV risk factors on the SCORE scale participated in a one-stage clinical research. A standard questionnaire was given to all patients, and HRQ conducted a thyroid status investigation.

According to the level of overall CV risk for SCORE, patients were classified into three groups: Low/moderate CV risk was 33.9 percent, high CV risk was 41.9 percent, and extremely high CV risk was 24.2 percent. The majority of the participants were between the ages of 50 and 59, and 60 and 69. 22.2 percent of patients in the 40-49 year age group had a high CV risk, 28% of men in the 50-59 year age range had a moderate CV risk, and 49.7% of older patients had a very high CV risk. According to the results of an HRQ questionnaire survey, 34.9 percent of patients have a low risk of developing hypertension, 48.9 percent have a moderate risk, and 16.1 percent have a high risk. According to the HRQ questionnaire, people who have a very high CV risk on the SCORE scale also have a high probability of acquiring the SH. Early signs of thyroid status problems should be discovered in individuals with one or more of the above CV risk factors, and the risk of developing hypertension should be examined. This strategy aids in the accurate assessment of the risk of SH in patients with NAFLD and the creation of primary preventative strategies.

Author(S) Details

Olena Kolesnikova
Government Institution «L.T.Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine.

Valeriya Nemtsova
Kharkiv National Medical University, Kharkiv, Ukraine.

Anna Isayeva
Government Institution «L.T.Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine.

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