Discussing the Diffusion Tensor Imaging without Complex Statistical Analysis Could Be Helpful for Diagnosis

Objective: The visualisation of fibre tracts in the brain is possible thanks to rapidly evolving technology. Yet data processing and analysis are becoming more complicated with the latest technologies. Currently, interpretations are mainly in-group research in these areas and are therefore not useful on the basis of individual patient assessments. In this regard, we investigated our cases with diffusion tensor imaging (DTI) and attempted to demonstrate whether or not the data could simply be interpreted by the eye of the radiologist.
Materials: Our study consisted of 31 cases with 3 Tesla Magnetic Resonance Imaging (MRI) units that were evaluated in our middle. For ischemia, posttraumatic axonal injury, congenital malformation, neoplasia, autism, mental retardation and epilepsy, Cranial DTI studies have been conducted. In neoplasia and ischemia cases, cranial DTI was performed to show successful fibre tracts and was used in other cases to classify any gross anomaly in micro structural anatomy in addition to standard traditional MRI. Along with fused traditional T1 weighted 3D high-resolution images and FA charts, DTI images were assessed. DTI was done during the patients’ first administration.
Results: DTI-FA images showed us important signal changes secondary to Wallerian degeneration in two cases, in addition to the chronic ischemic focus in patients with ischemia. While isointense in traditional series, FA values showed decreased values at the levels of axonal discontinuity in traumatic brain injury cases. In congenital malformation cases, major interaction and projection fibre defects were visualised in both fused 3D-DTI images and FA map images. Displacement, penetration, fibre degradation in cases of neoplasia have been clearly visualised. However, in all patients diagnosed with motor mental retardation, epilepsy or neuropsychiatric conditions, any objective abnormality has not been recorded.
Conclusion: In conclusion, although it does not provide useful concrete and case-specific information to radiologists, especially in cases of microstructural abnormalities such as neuropsychiatric disorders, epilepsy and motor-mental retardation, it is possible to obtain diagnostic information from DTI-FA maps and 3D-trac-tography images in most cases of organic pathologies. Indeed, statistical analysis programmes currently used could demonstrate microstructural anomalies as well as expand steadily and this field is the subject of ongoing study.

Author(s) Details

Duzgun Yildirim
Department of Medical Imaging, Acibadem University, Vocational School of Health Sciences, Istanbul, Turkey.

Deniz Alis
Acibadem Maslak Hospital, Department of Radiology, Istanbul, Turkey.

Gokhan Kuyumcu
Istanbul University, Cerrahpasa Medical Faculty, Department of Radiology, Istanbul, Turkey.

Selim Bakan
Istanbul University, Cerrahpasa Medical Faculty, Department of Radiology, Istanbul, Turkey.

Özlem Güngör
Istanbul Sancaktepe Prof. Dr. Ilhan Varank Training and Research Hospital, Department of Radiology, Istanbul, Turkey.

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