Determining the Role of Nuchal Translucency for Detection of Chromosomal Aberration in Vietnam


In order to identify chromosomal abnormalities, the current study examines the sensitivity and specificity of various nuchal translucency criteria. The sensitivities of nuchal translucency alone as a screening test for chromosomal abnormality with various cut-offs in a Vietnamese population are being compared for the first time in this study. This is a long-term study of pregnant women who had first trimester screening and ultrasound at the national hospital for obstetrics and gynecology’s diagnostic prenatal centre. In order to diagnose chromosomal abnormalities, the threshold of 2.5 mm for enhanced foetal nuchal translucency showed a sensitivity-specificity average of 87.25 percent and an OR of 242.799(95 percent CI: 60.004-982.465). In terms of diagnosing Down syndrome, it had an average sensitivity-specificity ratio of 86.85 percent. The average sensitivity-specificity ratio was 87.75 percent when used to diagnose chromosomal abnormalities specific to gender. In the diagnosis of other chromosomal aneuploidies, it showed an average sensitivity-specificity ratio of 85.95 percent. It exhibited an average sensitivity-specificity of 84.3 percent and an OR of 62.424 (95 percent CI: 15.583-768.096) for the diagnosis of structural chromosomal rearrangement. More than half of the chromosomally defective group among Vietnam’s foetuses with enhanced nuchal translucency had abnormalities other than trisomy 21. (52.2 percent ). The cutoff criterion for diagnosing chromosomal abnormalities is 2.5 mm, with an average sensitivity and specificity of 87.25 percent.

Author(s) Details:

Long Hai Nguyen,
Haiphong University of Medicine and Pharmacy, Hai Phong, Vietnam.

Cuong Danh Tran,
Hanoi Medical University, Hanoi, Vietnam.

Anh Toan Ngo,
National Hospital of Obstetrics and Gynecology, Hanoi, Vietnam.

Please see the link here:

Keywords: Chromosomal defects, amniocentesis, thresholds, sensitivity, specificity.

Leave A Comment