Determining the Effect of Injection Dexmedetomidine for Prevention of Pain due to Propofol Injection and Comparing it with Injection Lignocaine

Background: Local pain after a Propofol injection is a common occurrence. Different ways have been tried to alleviate the discomfort, but they have had mixed results. The purpose of this study was to examine the efficacy of injection Dexmedetomidine 0.2 mcg/kg against injection Lignocaine 0.2 mg/kg in preventing pain caused by Propofol injection.

Method: The study was started with written informed consent from the participants after receiving clearance from the Institutional Ethics Committee. In a randomised prospective trial, 60 ASA I and II patients between the ages of 20 and 60 years, of either sexe, were randomly assigned to one of two groups for elective procedures under general anaesthesia.

Injection Dexmedetomidine 0.2mcg/kg in Group I (Dexmedetomidine group), and

Injection Lignocaine 0.2 mg/kg in Group II (Lignocaine group).

In 5 mL normal saline, both were diluted. A 20 G cannula was used to secure the IV line, and a pneumatic tourniquet was used to apply venous occlusion to the forearm, which was inflated to 70mm Hg for 1 minute. After the study drug was injected, the tourniquet was removed and 25 percent of the predicted dose of Injection Propofol was administered intravenously over 10 seconds. The severity of pain was assessed using the McCrirrick and Hunter scale, after which the remaining Propofol and neuromuscular blocking drug were administered. Anesthesia was maintained with Oxygen, Nitrous oxide, and Isoflurane on intermittent positive pressure ventilation with Bain’s circuit after endotracheal intubation. Muscle relaxant injection Vecuronium was utilised.

Results: Demographic data revealed no statistically significant differences between the two groups. In terms of pain reduction due to injection Propofol, there was no statistically significant difference between the two groups. In both groups, no adverse effects such as oedema, discomfort, or wheal response at the injection site were noted.

Author(S) Details

Manisha A. Sapate
Department of Anaesthesiology, YCM Hospital, Pimpri, Pune, India.

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