Determining the Association of Neutrophil to Lymphocyte Ratio with Clinicopathological Features in Breast Cancer

Background: Breast cancer heterogeneity is produced by a variety of factors such as patient characteristics, co-morbidities, histology, immunochemistry, and the disease’s molecular type, leading in a wide range of treatment options. Despite advancements in breast cancer diagnosis and therapy, breast cancer remains the leading cause of death in Pakistani women. Several studies have found that chronic inflammatory disorders have a role in the progression of cancer; these factors also promote growth, which leads to a poor prognosis.

The goal of this study is to look at the neutrophil to lymphocyte ratio (NLR) in breast cancer patients’ blood and how it relates to disease characteristics.

The cross-sectional study was conducted in Karachi, Pakistan, at Liaquat National Hospital and Medical College. A total of 2059 female breast cancer patients met the criteria. A thorough blood count with leukocyte differential was recommended for the patients prior to surgery. Complete patient data, including specimen-related histopathology reports, was acquired prior to surgery. Patients with current infection/sepsis, blood issues, inflammatory or autoimmune disorders in the past or present, or steroid medication were excluded.

The NLR had no link to age, grade, or luminal subtypes, according to the findings. NLR, on the other hand, was found to have a strong link to the magnitude and stage of the disease. As NLR increased, the stage advanced.

Conclusion: The NLR ratio may be used as a diagnostic adjunct in the preoperative workup of patients with breast cancer in the future, according to the findings of this investigation.

Author(S) Details

Rufina Soomro
Liaquat National Hospital and Medical College, Karachi, Pakistan.

Namiya Cho
Liaquat National Hospital and Medical College, Karachi, Pakistan.

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