Design, Synthesis, and Anti-Tubercular Studies of 10-(phenylsulfonyl)pyrimido[1,2-a]benzimidazol (10H) One Derivatives

Sulfonamides are a special class of chemicals with outstanding antibacterial properties. Sulpha medicines were the first efficient chemotherapeutic agents used to treat bacterial infections in humans, and they were shown to be resistant to Mycobacterium tuberculosis, Typhoid and Paratyphoid bacilli, and other germs. N-sulfonation of 2-substituted-pyrimido[1,2- a]benzimidazol-4(10H)-ones yielded a series of new 10-phenylsulfonyl-2-substituted-4,10 dihydrobenzo[4,5]imidazo[1,2- a]pyrimidin-4-one derivatives, which were evaluated for in vitro anti-tuberculosis activity against Mycobacter

Author(S) Details

K. V. Jagannath
Department of Chemistry, Bengaluru City University, Central College Campus, Bengaluru-560001, India.

G. Krishnamurthy
Department of Chemistry, Bangalore University, Jnanabharathi Campus, Bengaluru-560056, India.

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