Deactivation DNA Polymerase and Hexokinase Enzymes by Radioisotope 28Mg in Cancer Treatment Research: An Advance Study


Cancer cells differ from healthy cells in that they multiply quickly, uncontrolled, and seldom die. For their metabolic operations, they require more enzymes in terms of quantity than healthy cells, including two enzymes in particular: hexokinase and DNA polymerase. Because they accelerate energy metabolism and DNA replication, enzymes are fascinating. The magnesium metal ion is a cofactor in both of them. A recent advance in cancer treatment research is the use of beta-decay radioisotopes to disable cofactor enzymes by replacing stable metals with beta-decay radioisotopes. In this investigation, 28Mg is employed to replace a stable Mg in the enzymes. Deactivated hexokinase has the ability to interrupt or stop the delivery of energy to tumour cells. If DNA polymerase is inactive, DNA replication might be hindered or disturbed. If these two critical pathways are interrupted, tumours may be stopped in their tracks and even eliminated. Deactivating radioactive isotopes, on the other hand, will assault tumour cells with a near-100 percent chance of hitting.

Author (s) Details

Tran Van Luyen
Vietnam Atomic Energy Institute, Vietnam.

View Book :-

Leave A Comment