Complementary Role of Bone Marrow Aspiration and Biopsy: A Retrospective Study


The goal of the current study was to demonstrate the complimentary roles of both procedures by comparing the outcomes of bone marrow aspiration (BMA) and bone marrow trephine biopsies (BMB). A bone marrow inquiry is necessary for the assessment of various haematological and non-hematological diseases. The two most often used procedures for diagnosis are bone marrow aspiration and bone marrow biopsy, and both work best when done at the same time. This retrospective study examined 74 cases of bone marrow examinations that were received by our institution’s pathology department from January 2019 to August 2020. Giemsa and iron stain were used to stain all aspirations, whereas normal H&E stain was used to stain all biopsy samples. IHC markers and reticulin dye were applied as needed. In cases of diverse haematological and non-hematological diagnoses, a bone marrow investigation is crucial. The aspirated smear is primarily used for cytologic details while the biopsy sections are primarily useful for cellularity, fibrosis, architectural pattern, metastatic deposits, and from the same tissue we can go for Immunohistochemistry. Bone marrow aspiration and biopsy using standard staining procedures, fixation, embedding, and cutting techniques, generally complement each other. As this is a relatively difficult invasive operation, appropriate technique should be kept in mind when doing BMA and BMB concurrently to maximise material yield and decrease patient discomfort by avoiding repeating the procedure owing to inadequate material.

Author(s) Details:

Nirali Shah,
Medical College, Baroda, Gujarat, India.

Vidhi Shah,
Medical College, Baroda, Gujarat, India.

Falguni Goswami,
Medical College, Baroda, Gujarat, India.

Roopam Gidwani,
Medical College, Baroda, Gujarat, India.

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Keywords: Granulomatous inflammation, MDS, Flow cytometry, IHC.

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