Comparative Study of Common Antioxidants and Dithiooxamide in Lipid Autoxidation


The writers have studied antioxidants, oxidation, and anti-aging since the 1980s. They learned that since lipids are some of the most widely used basic materials in foods, cosmetics, and the human body, it would be wise to look at autoxidation in this context, whether to stop spoilage or slow ageing.

The researchers selected a few lipids for an autoxidation inquiry and compared them to common pro-oxidants and antioxidants, as well as a possible antioxidant candidate, along with an evaluation of their short-term toxicity. The lipids were heated up while being subjected to a number of pro-oxidants, common commercial antioxidants, the antioxidant candidate, and a control. After that, the authors performed a short-term toxicity assessment and an analysis of the lipids for oxidation by-products. Autoxidation is more likely to occur in lipids that have been exposed to heavy metals like iron, copper, or other heavy metals or that have been polluted with them. In contrast to other metals, aluminium does not appear to hasten the autoxidation of lipids. The antioxidant candidate dithiooxamide appears to be a capable antioxidant with no short-term toxicity in a small sample study, which was far below the LDLo and LD50 conducted on rats and mice using dithioxamide in other later published research. This is in contrast to antioxidants like vitamin E, BHA, BHT, and PG. The results indicate that iron, copper, and other heavy metals should be avoided when using lipids, and that the antioxidant candidate dithiooxamide may be useful for exterior lipid applications when used sparingly.

Author(s) Details:

Seamus C. C. Phan,
10 Anson Road, #03-19, International Plaza, Singapore 079903, Singapore.

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Keywords: Autoxidation, antioxidant, lipid, anti-ageing, ferroptosis, dithiooxamide, toxicology.

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