Clinical Significance of Haptoglobin, an Acute Phase Protein


In the blood plasma, haptoglobin is an acute phase protein that has a high affinity for binding haemoglobin released from erythrocytes, reducing iron loss and renal injury while also inhibiting its oxidative activity. The acute phase response is modulated in a variety of ways by haptoglobin, which also possesses antibacterial properties. Since haptoglobin also has clinical relevance, it can be utilised to identify a variety of medical disorders. Humans can have one of three different haptoglobin phenotypes: Hp 1-1, Hp 2-1, or Hp 2-2. The Haptoglobin groups can be used in forensic research in cases of disputed paternity. We are all aware of how crucial it is to get trustworthy data for forensic science and study. Any inference made from a wealth of available evidence is trustworthy and unchallengeable. The gene frequency of these three haptoglobin phenotypes has been the subject of population studies all throughout the world. The study is an effort in this regard; it compares newly available data to changes in the percentage of distinct Haptoglobin types.


Author (s) Details

K. J. Joshi
Forensic Science Laboratory, Kalina, Mumbai, India.

B. T. Shah
Forensic Science Laboratory, Kalina, Mumbai, India.

V. R. Rathod
Forensic Science Laboratory, Kalina, Mumbai, India.


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Keywords –  Electrophoresis, genotype, gene frequency, haptoglobin, page, phenotype, population study

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