Extracellular or circulating nucleic acids (cfs) have long been used as a diagnostic or predictive tool in oncology. However, their use as noninvasive biomarkers in the therapy of infertility in gynaecology and obstetrics has grown common. In human pathophysiology, free nucleic acids provide a new source of diagnostic and/or prognostic biomarkers. Free DNA, which can be a long or short strand of DNA originating from apoptotic or necrotic processes, and free RNA containing it make up circulating nucleic acids. MicroRNAs (miRNA) are ribonucleic acids that are small in size. Short single-stranded (RNA) that can prevent a gene from producing proteins. Piwi interacting RNAs (piRNAs), which are tiny RNAs seen in germ cells and even early embryos, and small RNAs interfering (siRNAs), which are small RNAs capable of binding to a messenger RNA sequence and blocking gene expression by cleaving it. The presence of circulating nucleic acids in numerous biological fluids such as urine, seminal plasma, and serum, their ease of detection, the change in their levels based on the body’s pathophysiological state, and their involvement in many biological processes such as folliculogenesis, Circulating nucleic acids are essential and fascinating biomarkers for the management of male infertility because of steroidogenesis and spermatogenesis. They are a valuable supplement for those who practise medically assisted reproduction. Circulating nucleic acids, as a result, appear to be a promising path for preventing implantation failures. In this essay, we will try to emphasise their importance in the treatment of male infertility by highlighting their various applications.
Author (S) Details
Modou M. Mbaye
Laboratory of Physiopathology, Genetics Molecular and Biotechnology (PGMB), Faculty of Sciences Ain Chock, Research Center Health and Biotechnology, University Hassan II of Casablanca, Morocco. In Vitro Fertilization Center IRIFIV, IRIS Clinic, Casablanca, Morocco. Laboratory of Medical Analyses, Reproductive Biology, Labomac, Casablanca, Morocco.
Bouchra El Khalfi
Laboratory of Physiopathology, Genetics Molecular and Biotechnology (PGMB), Faculty of Sciences Ain Chock, Research Center Health and Biotechnology, University Hassan II of Casablanca, Morocco.
Achraf Zakaria
In Vitro Fertilization Center IRIFIV, IRIS Clinic, Casablanca, Morocco.
Noureddine Louanjli
In Vitro Fertilization Center IRIFIV, IRIS Clinic, Casablanca, Morocco. Laboratory of Medical Analyses, Reproductive Biology, Labomac, Casablanca, Morocco.
Mustafa Zakaria
Department of Reproductive Biology, Senior Clinical Embryology and Assisted Conception, Deputy, Northwestern University, Evanston, Illinois, USA; Executive Director and Administrative Coordinator of the Association for Scientific Research of the IRIFIV-AISRG Group, Consultant at the IRIFIV Fertility Center, IVF laboratory, Casablanca, Morocco.
Abdelaziz Soukri
Laboratory of Physiopathology, Genetics Molecular and Biotechnology (PGMB), Faculty of Sciences Ain Chock, Research Center Health and Biotechnology, University Hassan II of Casablanca, Morocco.
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