Phytochemical Investigation of Crotalaria Species-Isolation of a New Dihydro Chalcone from Crotalaria ramosissima

Natural items used to be mankind’s only source of medication. Plants use a variety of biosynthetic processes to create unexpected new structures that are physiologically active. Phytochemical examination of medicinal plants indicated the existence of a wide spectrum of pharmacologically active chemical elements such as alkaloids, flavonoids, saponins, glycosides, and triterpenoids. The genus Crotalaria, which […]

Determining the Enhancement of Oral Bioavailability VIA Solid Lipid Nanoparticles of Anticancer Drug Dasatinib – An In-vitro Cytotoxicity and Pharmacokinetic Study

Dasatinib (DST) is a Biopharmaceutics Classification System Class II medication with a high permeability and very low solubility. DST’s low water solubility and poor dissolution result in low bioavailability. As a result, restricted aqueous solubility represents a bottleneck for DST’s therapeutic success. Due to a large first-pass effect, animal research suggests that DST has an […]

Study on Utilization Pattern of Anti Dementia Drugs and Cost-Effective Analysis in India

Background: In India, the number of people suffering from Alzheimer’s disease (AD) and other dementias is expected to rise every year, owing to continuous growth in the elderly population and consistent increases in life expectancy. Aim: To assess the current state of clinical practise in India, as well as the cost of anti-dementia medications in […]

Investigation on Phytochemical Constituents and Antimicrobial Properties of Crude Flower Extract of Tecoma stans (L.) Juss. ex Kunth

The purpose of this study is to analyse the phytochemical profile and antibacterial activity of Tecoma stans (L.) ethanolic extract (TSEE) against Gram-positive and Gram-negative bacteria in vitro, because plants are utilised as medicinal agents. Tecoma stans is a perennial flowering shrub of the Bignoniaceae family. The entire plant has therapeutic potential and is used […]

Destabilization of Abnormal Methylation Enzymes as an Effective Therapeutic Strategy via Induction of Terminal Differentiation to Take Out Both Cancer Stem Cells and Cancer Cells

The goal of this research was to discover cancer medications that would kill both cancer stem cells (CSCs) and cancer cells, with a focus on CSCs because they were preventing traditional cancer treatments from working. The interaction of methylation enzymes with telomerase is a specific cancer cell defect. This anomaly keeps methylation enzymes extremely stable […]

Role of PKC in CD47-Mediated Phosphatidylserine Expression Pathway in Jurkat T Cells: A Preliminary Study

T-cell acute lymphoblastic leukaemia (T-ALL) treatment failure occurs when leukemic blasts develop resistance to chemotherapeutic drugs. The hunt for targets for the creation of more effective and less toxic anti-leukemic medicines is now underway. CD47 has been linked to chemo-resistance and cancer cell metastasis. Although numerous possible pathways have been proposed to explain the therapeutic […]

Development of a Discriminatory Drug Dissolution Method for Estimation of Rivaroxaban from Rivaroxaban Tablets

The purpose of this study is to develop a discriminate dissolving method that may be utilised as a release parameter for testing and assessing product performance in regulated markets utilising quality by design trials. Dissolution testing is required for all solid oral dosage forms and is utilised for product release and stability testing throughout the […]

Antimicrobial Studies: An Approach to Microbiological Assay

This article offers a brief overview of bacteria and fungi, as well as a list of regularly utilised bacteria and fungi for antimicrobial purposes. Types of approaches are also briefly covered in this chapter. For a better outcome, this article includes how minimum inhibitory concentration (MIC) is measured in research activity, as well as reported […]

Antioxidant and Anti-Osteosarcoma Effect of Edible Fungi Pleurotus ostreatus

Osteosarcoma is a rare primary tumour of the bone that accounts for less than 0.2 percent of all cancer cases. When compared to medicinal plants and phytoconstituents, it is treated with advanced medications that have significant negative effects. The primary goal of this research is to investigate the antibacterial activity, phytochemical screening, and anticancer activity […]

An Overview of Fast Dissolving Oral Thin Film

Many pharmaceutical companies are moving from tablets to oral thin films that dissolve quickly (OTFs). Films combine the benefits of tablets and liquid dosage forms (precise dosing, ease of administration) (easy swallowing, rapid bioavailability). According to statistics, four out of every five patients prefer orally dissolving dose forms to solid oral dosage forms. Solid dose […]