Assessment of In vitro Antimicrobial Activity of Two Different Synthesized Fatty Amides Derivatives against Some Microbial Pathogens: A Recent Study

In this present episode, two amide derivatives accompanying long chains; N-phenyldodecanamide (dodecanilide) 1 and N-cyclohexyloctamide 2 were synthesized and proven in vitro for a roomy array of antimicrobial activities against two Gram positive microorganisms (Bacillus subtilis, Staphylococcus aureus), four Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella enterica), and three mold fungi (Aspergillus carbonarius, Mucor ramannianus, Candida albicans), to judge their potential use as antimicrobial agents. The plate diffusion assay was used to decide the zones of inhibition of these compounds. The two amides’ meaningful antibacterial ventures were indicated apiece results. The newly synthesised oily N-cyclohexyloctamide 2 had antibacterial action against S. aureus and A. carbonarius, and was more direct against C. albicans due to bigger zones of inhibition than the earlier created oily anilide 1. Contrarily, the substituted fatty amide 2 was less active against S. enterica than the fatty anilide 1, that had higher decontaminating activity against P. aeruginosa. Based on these findings, it is doable to deduce that oily amide derivatives maybe used as cleansing ingredients and as potential beginnings for new medications that are productive against a variety of spreading diseases.

Author(s) Details:

Malki Fatiha,
Laboratoire De Recherche Sur Les Produits Bioactifs Et Valorisation De La Biomasse, Ecole Normale Supérieure, 16308,BP 92, Kouba, Algiers, Algeria.

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Keywords: Amide derivatives, antimicrobial activity, disk diffusion method, synthesis

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