Researchers are looking for alternatives to standard antibiotics, such as natural compounds with antibacterial action, due to the problem of multidrug-resistant pathogens including bacteria, fungi, and yeast, as well as the prohibition on using antibiotics as growth promoters in feed. Natural antimicrobial peptides and compounds isolated from animal secretions and some insect venoms have inspired a lot of interest and research because they have antimicrobial activity against infections with lesser resistance and higher synergistic effects when combined with blends of them. In this chapter, antimicrobial peptides generated from honeybee venom will be expressed in yeast Saccharomyces cerevisiae, as well as antimicrobial compounds isolated from giraffes and their inhibitory effects on liver microsomal enzymes. The activity of CYP450 against microorganisms such as Agrobacterium rhizogenes, Aspergillus niger, Candida albicans, and E.coli will be described using the optical density analysis method, and their minimum inhibitory concentrations (MIC) as well as ICs 50 to measure the potency to inhibit a biological function will be determined using programmes such as Gene5, graph pad prism, and clone manager, as well as antimicrobial action .

Author(S) Details

Al-Baraa Akram
Department of Pharmaceutical Biotechnology, De Montfort University, Leicester, UK.

Glen McCann
Department of Pharmaceutical Biotechnology, De Montfort University, Leicester, UK

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