An Evaluation of Single Electron Transfer Reduction Products of 3-Oxoindoles as Antibacterial Agents


Antimicrobial resistance is rapidly spreading over the world as a result of widespread and indiscriminate antibiotic use. Reduction of indole derivatives is an important and fascinating topic of synthetic organic chemistry since it is used to make a variety of medicines, dyes, agrochemicals, and higher alkaloids.

The goal of this study is to evaluate the antibacterial properties of six indole derivatives, namely 3-(Naphth-1-y methyl) –indole (II), 3-(1-Naphthylcarbonyl – indole (III), 3,3′ –diformyl-2,2′ –bis indole (IV), 1,4- (3,3′ –di indolyl) – 1.

Methods: The indole derivatives were synthesised from 3-formyl indole, which was further characterised by IR and NMR analyses. The antibacterial activity of the six produced compounds was tested using the agar diffusion method, and the results were validated using the microdilution technique to determine their MIC values.

Results: All of the compounds showed some activity against several bacterial species, with the exception of compound IV, which only showed activity against B. subtilis. Compound II was the most effective, with lower MIC values, against two Gram –ve and one Gram +ve bacteria, the Gram –ve bacteria being known to cause nosocomial and community-acquired illnesses. Conclusion: Molecule II, as the most effective active compound, might be used as a starting point for further optimization, with the potential to contribute as a broad spectrum antibiotic.

Author (s) Details

Debasish Bandyopadhyay
Department of Chemistry, The University of Texas-Pan American, West University Drive, Edinburg, TX 78539, USA.

Irani Biswas
Department of Botany, The University of Burdwan, Burdwan 713104, W. Bengal, India.

Subrata Laskar
Department of Chemistry, The University of Burdwan, Burdwan – 713104, W.Bengal, India.

Bidyut Basak
Department of Chemistry, The University of Burdwan, Burdwan – 713104, W.Bengal, India.

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