Advanced Formulation Techniques to Enhance Solubility, Dissolution and Bioavailability of Poorly Water- Soluble Drugs

 The rate and extent (amount) of unmodified medication absorption from its dose form is referred to as bioavailability. For a medicine to display maximum pharmacological response, this is considered a primary parameter. Poor aqueous-soluble drugs may have slow dissolving and inadequate absorption, resulting in low bioavailability. In designing formulations, the drug’s dissolving and solubility properties are critical. As a result, several approaches such as pH modification, micronization, solid dispersion, Supercritical fluid recrystallization, complexation, surfactant usage, co-solvency, precipitation, and nanotechnology are used to improve medication solubility. The primary goal of this research is to provide an overview of ways for improving the solubility, dissolution, and bioavailability of low water soluble pharmaceuticals, as well as the importance of Green chemistry in nanotechnology for the production of diverse nanosized formulations.

Author(s) Details:

G. S. Annammadevi,
Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, India.

V. Lavanya,
Mother Teresa College of Pharmacy, Affiliated to Osmania University, Hyderabad, India.

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